Consequences of degeneracy in network function.

Consequences of degeneracy in network function.
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DOI:
10.1016/j.conb.2016.07.008
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发表时间:
2016-12
影响因子:
5.7
通讯作者:
Weiss KR
Weiss KR
中科院分区:
医学2区
文献类型:
--
作者:
Cropper EC;Dacks AM;Weiss KR

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在网络中,不同的元素通常具有相似的功能。然而,目前尚不清楚这种网络退化是有益的,还是仅仅反映了相对于单个神经元特性对整体网络性能的更严格调节。我们回顾了数据强烈表明退化是有益的情况,因为它使网络功能更健壮。重要的是,网络退化可能会产生尚未得到广泛认可的功能性后果。当网络活动由具有持久操作的调制器配置时,这可能是正确的,并且网络活动的历史可能会影响后续功能。数据表明,这种情况下的退化可能对潜在记忆的产生和状态依赖的任务切换很重要。
Often distinct elements serve similar functions within a network. However, it is unclear whether this network degeneracy is beneficial, or merely a reflection of tighter regulation of overall network performance relative to individual neuronal properties. We review circumstances where data strongly suggest that degeneracy is beneficial in that it makes network function more robust. Importantly, network degeneracy is likely to have functional consequences that are not widely appreciated. This is likely to be true when network activity is configured by modulators with persistent actions, and the history of network activity potentially impacts subsequent functioning. Data suggest that degeneracy in this context may be important for the creation of latent memories, and for state-dependent task switching.
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