Blood pressure augmentation and maternal circulating concentrations of angiogenic factors at delivery in preeclamptic and uncomplicated pregnancies.
Blood pressure augmentation and maternal circulating concentrations of angiogenic factors at delivery in preeclamptic and uncomplicated pregnancies.
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DOI：
10.1016/j.ajog.2008.06.030
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发表时间：
2008-12
影响因子：
9.8
通讯作者：
Staff, Anne Cathrine
中科院分区：
文献类型：
--
作者：
Troisi, Rebecca;Braekke, Kristin;Harsem, Nina Kittelsen;Hyer, Marianne;Hoover, Robert N.;Staff, Anne Cathrine
这项研究的目的是确定血压升高是否与无并发症和先兆子痫妊娠的母体血管生成因子有关。在43例无并发症妊娠和44例先兆子痫妊娠中，分析了妊娠中晚期血压升高与分娩时母体血清可溶性fms样酪氨酸激酶受体（sFlt 1）、可溶性内皮素（sEng）和胎盘生长因子（PlGF）浓度的关系。在无并发症的妊娠中，舒张压和平均动脉压的升高与分娩时的PlGF呈负相关，与sEng和sFlt 1/PlGF比值呈正相关。在先兆子痫中，血压升高和血管生成因子浓度之间没有显著相关性。这些数据表明，血管生成因子参与血压正常妊娠的血压调节，并与血管生成平衡在无并发症妊娠中与中晚期血压升高相关的孕产妇乳腺癌风险降低中发挥作用的假设一致。
The objective of the study was to determine whether blood pressure increases are associated with maternal angiogenic factors in uncomplicated and preeclamptic pregnancies. Associations of blood pressure increases from mid- to late pregnancy with maternal serum concentrations of soluble fms-like tyrosine kinase receptor (sFlt1), soluble endoglin (sEng), and placental growth factor (PlGF) at delivery were analyzed in 43 uncomplicated and 44 preeclamptic pregnancies. In uncomplicated pregnancies, increases in diastolic and mean arterial pressure were inversely associated with PlGF at delivery and positively associated with sEng and sFlt1/PlGF ratio. There were no significant associations between blood pressure increases and angiogenic factor concentrations in preeclampsia. These data suggest that angiogenic factors are involved in blood pressure modulation in normotensive pregnancy and are consistent with the hypothesis that angiogenic balance plays a role in maternal breast cancer risk reduction associated with mid- to late blood pressure increases in uncomplicated pregnancies.
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影响因子：
10.3
作者：
Ekbom, A;Hsieh, CC;Trichopoulos, D
通讯作者：
Trichopoulos, D
妊娠前的子痫前期以及随后患乳腺癌的风险。
影响因子：
8.8
作者：
Vatten, LJ;Romundstad, PR;Trichopoulos, D;Skjærven, R
通讯作者：
Skjærven, R
DOI：
10.1016/j.ejogrb.2004.11.015
发表时间：
2005-09-01
期刊：
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
影响因子：
--
作者：
Staff, AC;Braekke, K;Holthe, MR
通讯作者：
Holthe, MR
影响因子：
82.9
作者：
Venkatesha, Shivalingappa;Toporsian, Mourad;Karumanchi, S. Ananth
通讯作者：
Karumanchi, S. Ananth
影响因子：
8.4
作者：
Parr, C;Watkins, G;Jiang, WG
通讯作者：
Jiang, WG