Iron, ferritin, hepatitis B surface and core antigens in the livers of chinese patients with hepatocellular carcinoma
Iron, ferritin, hepatitis B surface and core antigens in the livers of chinese patients with hepatocellular carcinoma
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中国肝细胞癌患者肝脏中铁、铁蛋白、乙型肝炎表面和核心抗原
作者：
Xin;L. Detolla;R. Custer;W. London
手术切除的标本，包括肿瘤和邻近的非肿瘤性肝组织，来自1983年3月至1984年7月期间在中华人民共和国上海医科大学附属中山医院的40例原发性肝癌患者。所有患者均为肝细胞癌（HCC），1例合并胆管癌。探讨了原发性肝癌患者肝组织中B肝炎病毒（HBV）标志物与铁及铁蛋白的关系。血清HBsAg（B型肝炎表面抗原）阳性率为80.0%（32/40）。肝硬化发生率为97.5%（39/40）。HBsAg在正常肝组织中的阳性率为82.5%（33/40），在肝癌组织中的阳性率为35.0%（14/40）（P < 0.001）。HBcAg（B核心抗原）在肝组织中的阳性率为25.0%（10/40），在肝癌组织中的阳性率为7.5%（3/40），两者差异有统计学意义（P < 0.05）。正常肝组织中65.0%（26/40）的血清铁含量高于肝癌组织中10.0%（4/40）的血清铁含量（P < 0.001）。铁蛋白在75%（30/40）的非肿瘤性肝脏和40%（16/40）的HCC组织中被证实（P < 0.001）。33例肝内HBsAg阳性细胞的HCC患者中有22例（66.7%）也显示了铁。在16例HCC细胞铁蛋白阳性患者中，仅在2例中发现铁。在非肿瘤性肝细胞中，10例HBcAg患者中有9例发现铁（P = 0.056）;这一发现与铁在复制HBV的细胞中蓄积的假设一致。其他结果表明：（1）HCC中的免疫组织学铁蛋白不是由于血清铁增加所致;（2）肿瘤细胞可能产生铁蛋白;（3）抗人肝铁蛋白的多克隆抗体与非肿瘤性肝细胞的反应比与HCC细胞的反应更好;（4）HCC中HBsAg和肝硬化的高患病率表明HBV在中国肝癌发生中起主要病因作用;（5）1例肝细胞癌是由于日本血吸虫感染引起的肝硬化。
Surgically resected specimens, consisting of tumor and adjacent non‐neoplastic liver tissue, were obtained from 40 patients with primary liver cancer at Zhong Shah Hospital, Shanghai Medical University, the People's Republic of China, between March 1983 and July 1984. All were hepatocellular carcinomas (HCC), one being admixed with cholangiocarcinoma. The relationship of hepatitis B virus (HBV) markers with iron and ferritin was evaluated in liver tissues from patients with primary liver cancers. The serum HBsAg (Hepatitis B surface antigen) positive rate was 80.0% (32/40). Cirrhosis was observed in 97.5% (39/40). HBsAg was identified in 82.5% (33/40) of uninvolved liver, and 35.0% (14/40) of HCC tissues (P < 0.001). HBcAg (hepatitis B core antigen) was detected in 25.0% (10/40) of liver, and 7.5% (3/40) of HCC tissues (P < 0.05). Stainable iron was found in 65.0% (26/40) of unaffected livers, and 10.0% (4/40) of HCC tissues (P < 0.001). Ferritin was demonstrated in 75% (30/40) of non‐neoplastic liver, and 40% (16/40) of HCC tissues (P < 0.001). Twenty‐two of 33 HCC patients (66.7%) with HBsAg positive cells in their livers also showed stainable iron. Of 16 patients positive for ferritin in HCC cells, iron was found in only two. Iron was found in nine of ten patients with HBcAg in non‐neoplastic hepatocytes (P = 0.056); a finding compatible with the hypothesis that iron accumulates in cells replicating HBV. The other results indicate that: (1) immunohistologic ferritin in HCC is not due to increased stainable iron; (2) tumor cells may produce ferritin; (3) polyclonal antibodies to human liver ferritin react better with non‐neoplastic hepatocytes than with HCC cells; (4) the high prevalence of HBsAg and cirrhosis in HCC suggests that HBV plays a major etiologic role in hepatocarcinogenesis in China; and (5) one case of HCC is attributed to Schistosoma japonicum infestation via cirrhosis.
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原发性肝细胞癌——病因、发病机制和预防。
影响因子：
3.3
作者：
London,WT
通讯作者：
London,WT
影响因子：
11.2
作者：
H. Hann;M. Stahlhut;I. Millman
通讯作者：
H. Hann;M. Stahlhut;I. Millman
树松鼠体内新发现的乙型肝炎病毒。
DOI：
10.1073/pnas.83.7.2233
发表时间：
1986
影响因子：
11.1
作者：
Feitelson,MA;Millman,I;Halbherr,T;Simmons,H;Blumberg,BS
通讯作者：
Blumberg,BS
DOI：
10.1073/pnas.78.5.3222
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
BLUMBERG, BS;LUSTBADER, ED;WHITFORD, PL
通讯作者：
WHITFORD, PL