Efficacy and Safety of LASIK Combined with Accelerated Corneal Collagen Cross-Linking for Myopia: Six-Month Study.
Efficacy and Safety of LASIK Combined with Accelerated Corneal Collagen Cross-Linking for Myopia: Six-Month Study.
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LASIK 联合加速角膜胶原交联治疗近视的疗效和安全性：为期六个月的研究。
DOI：
10.1155/2016/5083069
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发表时间：
2016
影响因子：
--
通讯作者：
Huang YF
中科院分区：
文献类型：
--
作者：
Wu Y;Tian L;Wang LQ;Huang YF
这是一项前瞻性对照临床试验。48例（96眼）近视患者纳入本研究。LASIK术后，应用加速角膜胶原交联（ACXL）进行近视治疗。在6个月的随访中，研究了LASIK-ACXL治疗的结果，并与单纯LASIK手术进行了比较。结果显示，随访6个月时，两组UDVA、CDVA、MRSE、K mean、角膜厚度、ECD差异均无统计学意义（均P > 0.05）。术后6个月，LASIK-ACXL组中有2只眼睛丧失了一行或多行视力，而所有仅接受LASIK治疗的眼睛均具有稳定的CDVA。体内共聚焦显微镜显示角膜细胞密度减少，前部残留基质床出现蜂窝状结构;仅接受LASIK手术后，这些变化相似，但更明显。在6个月的随访中，两组病例均未出现明显的角膜炎、退化或扩张体征。LASIK-ACXL能有效矫正近视患者的屈光不正，随访6个月无明显并发症，稳定性和形态学变化与单纯LASIK治疗相似。
This was a prospective controlled clinical trial. 48 myopia patients (96 eyes) were included in this study. After LASIK, accelerated corneal collagen cross-linking (ACXL) was used for myopia treatment. During 6-month follow-up, the results of LASIK-ACXL treatment were studied and compared to the LASIK-only procedure. The results showed that no statistically significant differences in UDVA, CDVA, MRSE, K mean, pachymetry, or ECD were found between the two groups at the visit after 6 months of follow-up (all P > 0.05). At 6 months postoperatively, 2 eyes lost one or more lines of visual acuity in the LASIK-ACXL group, whereas all LASIK-only treated eyes had a stable CDVA. In vivo confocal microscopy showed a decrease of keratocyte density and appearance of honeycomb-like structures in the anterior residual stroma bed; the changes were similar but more pronounced following LASIK-only. None of the cases in both groups developed signs of significant keratitis, regression, or ectasia during the 6-month follow-up. LASIK-ACXL can effectively correct refractive error in patients with myopia, with no significant complications during 6-month follow-up, indicating stability and morphologic change similar to those with LASIK-only treatment.
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影响因子：
2.8
作者：
Binder, Perry S.
通讯作者：
Binder, Perry S.
影响因子：
--
作者：
Chan, Annie;Ou, Judy;Manche, Edward E.
通讯作者：
Manche, Edward E.
影响因子：
2.4
作者：
Rad, AS;Jabbarvand, M;Saifi, N
通讯作者：
Saifi, N
影响因子：
4.2
作者：
Jones, SS;Azar, RG;Edelhauser, HF
通讯作者：
Edelhauser, HF
DOI：
10.1007/s00417-012-2220-4
发表时间：
2013-05-01
影响因子：
2.7
作者：
Gertnere, Jana;Solomatin, Igor;Sekundo, Walter
通讯作者：
Sekundo, Walter