Skin Wound Healing of the Adult Newt, Cynops pyrrhogaster: A Unique Re-Epithelialization and Scarless Model.
Skin Wound Healing of the Adult Newt, Cynops pyrrhogaster: A Unique Re-Epithelialization and Scarless Model.
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DOI：
10.3390/biomedicines9121892
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发表时间：
2021-12-13
期刊：
影响因子：
4.7
通讯作者：
Chiba C
中科院分区：
文献类型：
--
作者：
Ishii T;Takashimizu I;Casco-Robles MM;Taya Y;Yuzuriha S;Toyama F;Maruo F;Kishi K;Chiba C
在外科和美容研究中，无疤痕再生是治愈皮肤伤口的理想方法。要研究在医学上实现无疤痕皮肤伤口愈合的技术，动物模型是有用的。然而，包括人类在内的四足脊椎动物，在通过变态、孵化或出生过渡到陆地生命阶段时，通常会失去无疤痕再生的能力。因此，作为后天人类模型的动物一定是这一规则的例外，比如纽特。在这里，我们第一次详细地评估了成年蝾螈。利用日本火腹鳗，在不同部位切取全层皮肤，观察两年多来皮肤再上皮化、肉芽或真皮纤维化、质地、附属物及颜色(色调、色调和图案)的恢复情况。我们发现，成年蝾螈的皮肤最终通过独特的再上皮化过程和没有纤维瘢痕形成的过程再生得非常好，除了背侧到腹面的皮肤，其独特的颜色模式从未恢复。颜色模式因物种而异。因此，成虫为研究人类出生后皮肤创伤的完美愈合和再生提供了一个理想的模型系统。
In surgical and cosmetic studies, scarless regeneration is an ideal method to heal skin wounds. To study the technologies that enable scarless skin wound healing in medicine, animal models are useful. However, four-limbed vertebrates, including humans, generally lose their competency of scarless regeneration as they transit to their terrestrial life-stages through metamorphosis, hatching or birth. Therefore, animals that serve as a model for postnatal humans must be an exception to this rule, such as the newt. Here, we evaluated the adult newt in detail for the first time. Using a Japanese fire-bellied newt, Cynops pyrrhogaster, we excised the full-thickness skin at various locations on the body, and surveyed their re-epithelialization, granulation or dermal fibrosis, and recovery of texture and appendages as well as color (hue, tone and pattern) for more than two years. We found that the skin of adult newts eventually regenerated exceptionally well through unique processes of re-epithelialization and the absence of fibrotic scar formation, except for the dorsal-lateral to ventral skin whose unique color patterns never recovered. Color pattern is species-specific. Consequently, the adult C. pyrrhogaster provides an ideal model system for studies aimed at perfect skin wound healing and regeneration in postnatal humans.
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影响因子：
5.7
作者：
Brown MS;Ashley B;Koh A
通讯作者：
Koh A
影响因子：
4.7
作者：
Casco-Robles MM;Yasuda K;Yahata K;Maruo F;Chiba C
通讯作者：
Chiba C
影响因子：
6.5
作者：
Campbell, Laura;Saville, Charis R.;Murray, Peter J.;Cruickshank, Sheena M.;Hardman, Matthew J.
通讯作者：
Hardman, Matthew J.
影响因子：
1.5
作者：
Bertolotti, Evelina;Malagoli, Davide;Franchini, Antonella
通讯作者：
Franchini, Antonella
影响因子：
2.5
作者：
Casco-Robles, Martin Miguel;Yamada, Shouta;Chiba, Chikafumi
通讯作者：
Chiba, Chikafumi