Auditory cortical field coding long-lasting tonal offsets in mice.
Auditory cortical field coding long-lasting tonal offsets in mice.
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DOI：
10.1038/srep34421
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发表时间：
2016-09-30
影响因子：
4.6
通讯作者：
Shibuki K
中科院分区：
文献类型：
--
作者：
Baba H;Tsukano H;Hishida R;Takahashi K;Horii A;Takahashi S;Shibuki K
尽管时间信息处理在听觉感知中很重要，但编码音调偏移的机制尚不清楚。我们使用小鼠黄素蛋白荧光成像研究了在音调刺激偏移时引起的皮质反应。在持续 7 秒的音调刺激的偏移处可以清楚地观察到失调反应，但在持续 1 秒的刺激后则没有观察到失调反应。当在刺激之前持续 5-20 秒的调节音调刺激时，类似的皮质区域也会出现对短刺激的失调反应。 NMDA 受体抑制剂 MK-801 抑制了两种类型的失反应，表明 NMDA 受体依赖性突触抑制产生的去抑制可能与失反应有关。峰值偏离响应位于初级听觉皮层附近的一个小区域，并且没有发现响应峰值的频率依赖性偏移。不需要将先前的音调刺激与短测试刺激进行频率匹配来诱导对短刺激的失调反应。双光子钙成像显示，与对持续 1 秒的刺激的失调反应相比，在该区域中，神经元对持续 7 秒的刺激的失调反应明显更大。目前的结果表明存在对长期音调偏移做出反应的听觉皮层场，可能用于时间信息处理。
Although temporal information processing is important in auditory perception, the mechanisms for coding tonal offsets are unknown. We investigated cortical responses elicited at the offset of tonal stimuli using flavoprotein fluorescence imaging in mice. Off-responses were clearly observed at the offset of tonal stimuli lasting for 7 s, but not after stimuli lasting for 1 s. Off-responses to the short stimuli appeared in a similar cortical region, when conditioning tonal stimuli lasting for 5–20 s preceded the stimuli. MK-801, an inhibitor of NMDA receptors, suppressed the two types of off-responses, suggesting that disinhibition produced by NMDA receptor-dependent synaptic depression might be involved in the off-responses. The peak off-responses were localized in a small region adjacent to the primary auditory cortex, and no frequency-dependent shift of the response peaks was found. Frequency matching of preceding tonal stimuli with short test stimuli was not required for inducing off-responses to short stimuli. Two-photon calcium imaging demonstrated significantly larger neuronal off-responses to stimuli lasting for 7 s in this field, compared with off-responses to stimuli lasting for 1 s. The present results indicate the presence of an auditory cortical field responding to long-lasting tonal offsets, possibly for temporal information processing.
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影响因子：
25
作者：
Bandyopadhyay, Sharba;Shamma, Shihab A.;Kanold, Patrick O.
通讯作者：
Kanold, Patrick O.
DOI：
10.1111/j.1601-183x.2010.00570.x
发表时间：
2010-06-01
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Gaub S;Groszer M;Fisher SE;Ehret G
通讯作者：
Ehret G
DOI：
10.1111/ejn.12478
发表时间：
2014-03
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Joachimsthaler B;Uhlmann M;Miller F;Ehret G;Kurt S
通讯作者：
Kurt S
影响因子：
25
作者：
Jin, Jianzhong Z.;Weng, Chong;Alonso, Jose-Manuel
通讯作者：
Alonso, Jose-Manuel
影响因子：
2.7
作者：
de Lima, MNM;Laranja, DC;Schröder, N
通讯作者：
Schröder, N