Cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) in shark fins.

Cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) in shark fins.
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DOI:
10.3390/md10020509
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发表时间:
2012-02
期刊:
影响因子:
5.4
通讯作者:
Mash DC
Mash DC
中科院分区:
医学2区
文献类型:
--
作者:
Mondo K;Hammerschlag N;Basile M;Pablo J;Banack SA;Mash DC

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鲨鱼是最受威胁的海洋物种之一。全球人口正在下降,以支持对鱼翅汤不断增长的需求。众所周知,鲨鱼会在生物体内积累毒素,可能对鲨鱼产品的消费者造成健康风险。鲨鱼的食性多种多样,包括鱼类、哺乳动物、甲壳类和浮游生物。蓝藻神经毒素 β-N-甲氨基-L-丙氨酸 (BMAA) 已在自由生活的海洋蓝藻物种中检测到,并且可能在海洋食物网中生物累积。在这项研究中,我们从南佛罗里达州七种不同种类的鲨鱼身上采集了鳍片样本,利用 HPLC-FD 和三重四极杆 LC/MS/MS 方法调查了 BMAA 的发生情况。在所有受检物种的鳍中均检测到 BMAA,浓度范围为 144 至 1836 ng/mg 湿重。由于 BMAA 与神经退行性疾病有关,因此这些结果可能与人类健康具有重要相关性。我们认为,食用鱼翅可能会增加人类接触蓝藻神经毒素 BMAA 的风险。
Sharks are among the most threatened groups of marine species. Populations are declining globally to support the growing demand for shark fin soup. Sharks are known to bioaccumulate toxins that may pose health risks to consumers of shark products. The feeding habits of sharks are varied, including fish, mammals, crustaceans and plankton. The cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) has been detected in species of free-living marine cyanobacteria and may bioaccumulate in the marine food web. In this study, we sampled fin clips from seven different species of sharks in South Florida to survey the occurrence of BMAA using HPLC-FD and Triple Quadrupole LC/MS/MS methods. BMAA was detected in the fins of all species examined with concentrations ranging from 144 to 1836 ng/mg wet weight. Since BMAA has been linked to neurodegenerative diseases, these results may have important relevance to human health. We suggest that consumption of shark fins may increase the risk for human exposure to the cyanobacterial neurotoxin BMAA.
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