Odor identification deficits are associated with increased risk of neuropsychiatric complications in patients with Parkinson's disease.
Odor identification deficits are associated with increased risk of neuropsychiatric complications in patients with Parkinson's disease.
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DOI：
10.1002/mds.23234
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发表时间：
2010-10-15
影响因子：
8.6
通讯作者：
Siderowf, Andrew
中科院分区：
文献类型：
--
作者：
Stephenson, Randolph;Houghton, David;Sundarararjan, Sri;Doty, Richard L.;Stern, Matthew;Xie, Sharon X.;Siderowf, Andrew
嗅觉缺陷出现在帕金森病 (PD) 病程的早期，但其预后意义尚不清楚。本研究的目的是确定嗅觉障碍的严重程度是否与随后发生帕金森病并发症的风险相关。一百名 PD 患者自行进行了宾夕法尼亚大学气味识别测试 (UPSIT)。自初次诊断之日起平均 3.6 年进行测试。 PD 神经精神特征的发生率，包括认知能力下降和幻视，是在平均 6.8 年的随访后通过图表审查确定的。还获得了包括跌倒和运动障碍在内的运动结果的发生率。在嗅觉测试分数下降的四分位数中，神经精神并发症的风险有显着增加的趋势。此外，嗅觉表现最低四分位数的受试者比参考四分位数的受试者具有显着更高的调整后幻觉风险（HR = 4.70，95% CI 1.64，13.42）和认知能力下降（HR = 3.10，95% CI 1.05，9.21）。嗅觉功能障碍和运动障碍之间没有关联，与跌倒风险的关联性非常小。这些发现表明，病程早期嗅觉障碍的严重程度可能是帕金森神经精神并发症风险的有用标志。
Olfactory deficits appear early in the course of Parkinson’s disease (PD) but their prognostic significance is not known. The goal of this study was to determine whether the severity of olfactory impairment is associated with subsequent risk of developing complications of PD. One hundred patients with PD self-administered the University of Pennsylvania Smell Identification Test (UPSIT). Testing was done, on average, 3.6 years from the time of initial diagnosis. The incidence of neuropsychiatric features of PD, including cognitive decline and visual hallucinations, was ascertained through chart review after an average of 6.8 years of follow-up. Incidence of motor outcomes including falls and dyskinesias was also obtained. There was a significant trend for increased risk of neuropsychiatric complications across declining quartiles of olfactory test scores. In addition, subjects in the lowest quartile of olfactory performance had a significantly higher adjusted risk of hallucinations (HR = 4.70, 95% CI 1.64, 13.42) and cognitive decline (HR = 3.10, 95% CI 1.05, 9.21) than those in the reference quartile. There was no association between olfactory dysfunction and dyskinesias, and a very modest association with risk of falls. These findings suggest that severity of olfactory impairment early in the disease course may be a useful marker for the risk of neuropsychiatric complications of PD.
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影响因子：
9.9
作者：
Olichney, JM;Galasko, D;Thal, LJ
通讯作者：
Thal, LJ
影响因子：
2.9
作者：
DOTY, RL;SHAMAN, P;DANN, M
通讯作者：
DANN, M
影响因子：
9.9
作者：
GOETZ, CG;STEBBINS, GT
通讯作者：
STEBBINS, GT
DOI：
10.1093/jnen/61.5.413
发表时间：
2002-05-01
影响因子：
3.2
作者：
Del Tredici, K;Rüb, U;Braak, H
通讯作者：
Braak, H
影响因子：
9.9
作者：
Levy, G;Tang, MX;Marder, K
通讯作者：
Marder, K