Obesity and cancer risk: recent review and evidence.
Obesity and cancer risk: recent review and evidence.
复制标题
DOI：
10.1007/s11912-010-0139-7
复制
发表时间：
2011-02
影响因子：
4.7
通讯作者：
Chang, Maria
中科院分区：
文献类型：
--
作者：
Basen-Engquist, Karen;Chang, Maria
关键词：
超重和肥胖的流行率在世界范围内不断增加，肥胖和癌症之间联系的证据基础也在不断增加。在美国，每年约有85，000例新发癌症病例与肥胖有关。最近的研究发现，随着体重指数增加5 kg/m2，癌症死亡率增加10%。此外，对接受减肥手术的患者进行的研究报告称，癌症发病率和死亡率降低，特别是女性。这篇综述的目的是提供最新的研究，重点是肥胖和癌症之间的联系的流行病学研究。此外，我们将简要回顾肥胖和癌症之间关系的假设机制。未来研究的优先事项包括对潜在机制的额外工作，以及检查生活方式行为改变和减肥干预对癌症和中间生物标志物的影响的试验。
The prevalence of overweight and obesity is increasing worldwide, and the evidence base for a link between obesity and cancer is growing. In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%. Additionally, studies of patients who have had bariatric surgery for weight loss report reductions in cancer incidence and mortality, particularly for women. The goal of this review is to provide an update of recent research, with a focus on epidemiologic studies on the link between obesity and cancer. In addition, we will briefly review hypothesized mechanisms underlying the relationship between obesity and cancer. High priorities for future research involve additional work on the underlying mechanisms, and trials to examine the effect of lifestyle behavior change and weight loss interventions on cancer and intermediate biomarkers.
登录
查看更多内容
影响因子：
168.9
作者：
Renehan, Andrew G.;Tyson, Margaret;Zwahlen, Marcel
通讯作者：
Zwahlen, Marcel
影响因子：
51.1
作者：
Key, Timothy J.;Appleby, Paul N.;Reeves, Gillian K.;Roddam, Andrew W.
通讯作者：
Roddam, Andrew W.
影响因子：
8.9
作者：
Brown, T.;Avenell, A.;Summerbell, C.
通讯作者：
Summerbell, C.
影响因子：
4.9
作者：
Kelly, T.;Yang, W.;He, J.
通讯作者：
He, J.
影响因子：
158.5
作者：
Calle, EE;Rodriguez, C;Thun, MJ
通讯作者：
Thun, MJ