Blockade of glutamate reuptake in the rat nucleus accumbens increases locomotor activity.

Blockade of glutamate reuptake in the rat nucleus accumbens increases locomotor activity.
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阻断大鼠伏隔核中谷氨酸的再摄取会增加运动活性。

DOI:
10.1016/s0006-8993(98)01353-5
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发表时间:
1999
期刊:
影响因子:
2.9
通讯作者:
Vezina,P
Vezina,P
中科院分区:
医学3区
文献类型:
--
作者:
Kim,JH;Vezina,P

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The effect on locomotor activity of blocking glutamate reuptake in the nucleus accumbens (NAcc) was investigated in the rat. Bilateral intracranial microinjections into the NAcc of the selective glutamate reuptake blocker, l-trans-pyrrolidine-2,4-dicarboxylic acid (PDC), were made in the freely moving rat and locomotor activity subsequently measured for 2 h. Different groups of rats injected with one of three doses of PDC (0.5, 5 or 10 nmole/0.5 μl/side) showed significant dose-dependent increases in both horizontal and vertical locomotor activity relative to control rats that received injections of the saline vehicle. These findings indicate that glutamate in the NAcc plays an important role in the production of locomotor behaviors.
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