Pathological tumor volume predicts survival outcomes in oral squamous cell carcinoma.
Pathological tumor volume predicts survival outcomes in oral squamous cell carcinoma.
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DOI：
10.3892/ol.2018.8951
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发表时间：
2018-08
期刊：
影响因子：
2.9
通讯作者：
Hasegawa Y
中科院分区：
文献类型：
--
作者：
Mukoyama N;Suzuki H;Hanai N;Sone M;Hasegawa Y
本研究旨在探讨病理肿瘤体积（PTV）是否与口腔鳞状细胞癌（SCC）和临床淋巴结转移患者的生存结局相关。入组了47例未经术前治疗而接受根治性手术的患者。根据三维直径计算未经术前治疗而手术切除的原发肿瘤的PTV。使用考克斯比例风险模型进行生存分析。在单因素分析中，PTV ≥18 cm 3与总生存期（P<0.01）和局部无复发生存期（P<0.01）显著相关。多因素分析显示，PTV ≥18 cm 3与总生存期（P<0.01）和局部无复发生存期（P <0.01）显著相关。目前的研究结果表明，PTV在口腔鳞癌提供了一个预后参数，可以预测更短或更长的整体和局部无复发生存。
The present study examined whether the pathological tumor volume (PTV) was correlated with the survival outcomes in patients with oral squamous cell carcinoma (SCC) and clinical lymph node metastasis. Forty-seven patients who underwent radical surgery without preoperative treatment were enrolled. The PTV of the primary tumor, which was surgically resected without preoperative treatment, was calculated based on the diameters in three dimensions. A survival analysis was performed using a Cox proportional hazards model. A PTV of ≥18 cm3 was significantly correlated with shorter overall survival (P<0.01) and local recurrence-free survival (P<0.01) in a univariate analysis. A multivariate analysis with adjustment for the pathological stage (stage I–II/III–IV), primary site (tongue/others) and positive surgical margin and/or extracapsular extension (absent/present) showed that a PTV of ≥18 cm3 was significantly correlated with shorter overall survival (P<0.01) and local recurrence-free survival (P<0.01). The present findings suggested that PTV in oral SCC provides a prognostic parameter that may predict shorter or longer overall and local recurrence-free survival.
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