Recent advances in simultaneous analysis of bisphenol A and its conjugates in human matrices: Exposure biomarker perspectives.
Recent advances in simultaneous analysis of bisphenol A and its conjugates in human matrices: Exposure biomarker perspectives.
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DOI：
10.1016/j.scitotenv.2016.07.062
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发表时间：
2016-12-01
影响因子：
9.8
通讯作者：
Arora, Manish
中科院分区：
文献类型：
--
作者：
Andra, Syam S.;Austin, Christine;Yang, Juan;Patel, Dhavalkumar;Arora, Manish
人类接触双酚 A (BPA) 已引起全球健康界的广泛关注，它是主要的环境污染物之一，具有潜在的不利健康影响，包括内分泌干扰。目前测量 BPA 暴露的做法包括测量非结合 BPA（糖苷配基）和总 BPA（结合和非结合）；两次测量之间的差异导致对共轭形式的估计。然而，由于样品采集和分析过程中背景源的潜在干扰，将 BPA 作为最终分析物进行测量会导致估算不准确。 BPA 葡萄糖苷酸 (BPAG) 和硫酸盐 (BPAS) 是 BPA 暴露生物标志物的更好候选者，因为它们需要体内代谢并且不易受到外部污染。在这项工作中，主要重点是回顾可用于定量 BPA 缀合物的分析方法的最新技术水平。涵盖了同时提取和检测苷元 BPA 和缀合物的整个分析程序，从样品预处理、提取、分离、电离和检测。固相萃取结合液相色谱仪和串联质谱仪分析可提供最灵敏的 BPA 结合物检测和定量。本文讨论的是 BPA 结合物分析在人体暴露评估研究中的应用。测量 BPA 暴露的这些潜在生物标志物直到最近才在分析上变得可行，并且生物监测研究中存在需要克服的局限性和挑战。
Human exposures to bisphenol A (BPA) has attained considerable global health attention and represents one of the leading environmental contaminants with potential adverse health effects including endocrine disruption. Current practice of measuring of exposure to BPA includes the measurement of unconjugated BPA (aglycone) and total (both conjugated and unconjugated) BPA; the difference between the two measurements leads to estimation of conjugated forms. However, the measurement of BPA as the end analyte leads to inaccurate estimates from potential interferences from background sources during sample collection and analysis. BPA glucuronides (BPAG) and sulfates (BPAS) represent better candidates for biomarkers of BPA exposure, since they require in vivo metabolism and are not prone to external contamination. In this work, the primary focus was to review the current state of the art in analytical methods available to quantitate BPA conjugates. The entire analytical procedure for the simultaneous extraction and detection of aglycone BPA and conjugates is covered, from sample pre-treatment, extraction, separation, ionization, and detection. Solid phase extraction coupled with liquid chromatograph and tandem mass spectrometer analysis provides the most sensitive detection and quantification of BPA conjugates. Discussed herein are the applications of BPA conjugates analysis in human exposure assessment studies. Measuring these potential biomarkers of BPA exposure has only recently become analytically feasible and there are limitations and challenges to overcome in biomonitoring studies.
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新生儿重症监护室早产儿接触双酚A和其他酚类物质。
影响因子：
10.4
作者：
Calafat, Antonia M.;Weuve, Jennifer;Ye, Xiaoyun;Jia, Lily T.;Hu, Howard;Ringer, Steven;Huttner, Ken;Hauser, Russ
通讯作者：
Hauser, Russ
影响因子：
10.4
作者：
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通讯作者：
Heindel JJ
DOI：
10.1080/02652030802563290
发表时间：
2008-12-01
影响因子：
2.9
作者：
Cao, Xu-Liang;Corriveau, Jeannette
通讯作者：
Corriveau, Jeannette
影响因子：
2
作者：
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通讯作者：
Popovic, Svetlana
影响因子：
8.8
作者：
Cao, Xu-Liang;Corriveau, Jeannette;Jin, Xiaolei
通讯作者：
Jin, Xiaolei