Prevalence of oral HPV infection in the United States, 2009-2010.
Prevalence of oral HPV infection in the United States, 2009-2010.
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DOI：
10.1001/jama.2012.101
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发表时间：
2012-02-15
期刊：
影响因子：
--
通讯作者：
Chaturvedi AK
中科院分区：
文献类型：
--
作者：
Gillison ML;Broutian T;Pickard RK;Tong ZY;Xiao W;Kahle L;Graubard BI;Chaturvedi AK
人乳头瘤病毒（HPV）感染是一种独特形式的口咽鳞状细胞癌的主要原因，在美国男性中的发病率正在增加。然而，对口腔HPV感染的流行病学知之甚少。确定美国口腔HPV感染的患病率。作为2009-2010年国家健康和营养检查调查（NHANES）的一部分，进行了一项横断面研究，该调查是美国平民非机构化人口的统计代表性样本。在移动的检查中心接受检查的14至69岁的男女都有资格。参与者（N=5579）提供了30秒的口腔冲洗和漱口水。对于HPV类型的检测，从口腔脱落细胞纯化的DNA进行了评价聚合酶链反应和类型特异性杂交。通过标准化访谈获得人口统计学和行为数据。统计分析使用NHANES样本权重提供美国人群的加权患病率估计值。口腔HPV感染的流行。14 - 69岁男性和女性的口腔HPV感染率为6.9%（95%CI，5.7%-8.3%），HPV 16型为1.0%（95%CI，0.7%-1.3%）。口腔HPV感染在年龄方面遵循双峰模式，在30至34岁（7.3%; 95%CI，4.6%-11.4%）和60至64岁（11.4%; 95%CI，8.5%-15.1%）的个体中患病率最高。男性任何口腔HPV感染的患病率均显著高于女性（10.1% [95%CI，8.3%-12.3%] vs 3.6% [95%CI，2.6%-5.0%]，P<0.001;未校正的患病率[PR]，2.80 [95%CI，2.02-3.88]）。感染在没有任何类型性接触史的人中较不常见（0.9% [95% CI，0.4%-1.8%] vs 7.5% [95% CI，6.1%-9.1%]，P<0.001; PR，8.69 [95%CI，3.91-19.31]），并随着性伴侣数量（趋势P<.001）和每天吸烟量（趋势P<.001）而增加。在多变量模型中，年龄、性别、性伴侣数量和当前每天吸烟数量与口腔HPV感染独立相关。在美国14至69岁的男性和女性中，口腔HPV感染的总体患病率为6.9%，男性患病率高于女性。
Human papillomavirus (HPV) infection is the principal cause of a distinct form of oropharyngeal squamous cell carcinoma that is increasing in incidence among men in the United States. However, little is known about the epidemiology of oral HPV infection. To determine the prevalence of oral HPV infection in the United States. A cross-sectional study was conducted as part of the National Health and Nutrition Examination Survey (NHANES) 2009–2010, a statistically representative sample of the civilian noninstitutionalized US population. Men and women aged 14 to 69 years examined at mobile examination centers were eligible. Participants (N=5579) provided a 30-second oral rinse and gargle with mouthwash. For detection of HPV types, DNA purified from oral exfoliated cells was evaluated by polymerase chain reaction and type-specific hybridization. Demographic and behavioral data were obtained by standardized interview. Statistical analyses used NHANES sample weights to provide weighted prevalence estimates for the US population. Prevalence of oral HPV infection. The prevalence of oral HPV infection among men and women aged 14 to 69 years was 6.9% (95% CI, 5.7%–8.3%) and of HPV type 16 was 1.0% (95% CI, 0.7%–1.3%). Oral HPV infection followed a bimodal pattern with respect to age, with peak prevalence among individuals aged 30 to 34 years (7.3%; 95% CI, 4.6%–11.4%) and 60 to 64 years (11.4%; 95% CI, 8.5%–15.1%). Men had a significantly higher prevalence than women for any oral HPV infection (10.1% [95% CI, 8.3%–12.3%] vs 3.6% [95% CI, 2.6%–5.0%], P<.001; unadjusted prevalence ratio [PR], 2.80 [95% CI, 2.02–3.88]). Infection was less common among those without vs those with a history of any type of sexual contact (0.9% [95% CI, 0.4%–1.8%] vs 7.5% [95% CI, 6.1%–9.1%], P<.001; PR, 8.69 [95% CI, 3.91–19.31]) and increased with number of sexual partners (P<.001 for trend) and cigarettes smoked per day (P<.001 for trend). Associations with age, sex, number of sexual partners, and current number of cigarettes smoked per day were independently associated with oral HPV infection in multivariable models. Among men and women aged 14 to 69 years in the United States, the overall prevalence of oral HPV infection was 6.9%, and the prevalence was higher among men than among women.
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影响因子：
2
作者：
DURRLEMAN, S;SIMON, R
通讯作者：
SIMON, R
DOI：
10.1056/nejmoa0909537
发表时间：
2011-02-03
期刊：
The New England journal of medicine
影响因子：
--
作者：
Giuliano AR;Palefsky JM;Goldstone S;Moreira ED Jr;Penny ME;Aranda C;Vardas E;Moi H;Jessen H;Hillman R;Chang YH;Ferris D;Rouleau D;Bryan J;Marshall JB;Vuocolo S;Barr E;Radley D;Haupt RM;Guris D
通讯作者：
Guris D
影响因子：
8.8
作者：
Broutian, Tatevik R.;He, Xin;Gillison, Maura L.
通讯作者：
Gillison, Maura L.
影响因子：
11.8
作者：
Hernandez BY;Wilkens LR;Zhu X;Thompson P;McDuffie K;Shvetsov YB;Kamemoto LE;Killeen J;Ning L;Goodman MT
通讯作者：
Goodman MT
影响因子：
6.4
作者：
Hariri, Susan;Unger, Elizabeth R.;Markowitz, Lauri E.
通讯作者：
Markowitz, Lauri E.