Intergenerational effect of weight gain in childhood on offspring birthweight.
Intergenerational effect of weight gain in childhood on offspring birthweight.
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DOI：
10.1093/ije/dyp168
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发表时间：
2009-06
影响因子：
7.7
通讯作者：
Victora CG
中科院分区：
文献类型：
--
作者：
Horta BL;Gigante DP;Osmond C;Barros FC;Victora CG
背景一些研究表明，儿童期体重增加可能会增加成年后患慢性疾病的风险，最近的研究注意到体重增加的时间可能与其长期后果有关。然而，儿童期体重增加有明显的短期益处，关于儿童期体重增加的利弊的文献有限。方法在1982年，所有5914医院出生（超过99%的所有分娩）发生在Pelalanche，巴西南部，进行了识别和前瞻性研究，在几个场合。在2004-05年，我们试图追踪整个队列，并收集后代出生体重的信息。条件生长模型用于评估后代出生体重与出生至20个月和20至42个月体重增加之间的关联。结果2004 ~ 2005年共调查4297人，随访率为77.4%。这份手稿包括来自848名已经分娩的妇女和525名平均年龄为23岁的父亲的数据。母亲出生体重、20月龄时的体重和身长Z评分与下一代出生体重呈正相关，而父亲变量与结局无关。有条件的生长模型分析表明，在出生后的前20个月内体重增加速度快于预期的妇女会有更重的婴儿，而父亲的体重增加与此无关。对于出生体重与胎龄比处于最低三分位数的母亲，这种关联最强。结论母亲而非父亲的出生体重和儿童早期体重增加与下一代出生体重呈正相关。
Background Some studies suggest that weight gain in childhood may increase the risk of chronic diseases in adulthood, and recent studies have noticed that the timing of weight gain may be related to its long-term consequence. However, weight gain in childhood has clear short-term benefits, and the literature on the pro and cons of weight gain in childhood is limited. Methods In 1982, all 5914 hospital births (over 99% of all deliveries) occurring in Pelotas, Southern Brazil, were identified and studied prospectively on several occasions. In 2004–05, we attempted to trace the whole cohort and information on offspring birthweight was collected. Conditional growth modelling was used to assess the association between offspring birthweight and weight gain from birth to 20 months, and from 20 to 42 months. Results In 2004–05, we interviewed 4297 subjects, with a follow-up rate of 77.4%. This manuscript includes data from 848 women who had already delivered a child and 525 men who were fathers at the mean age of 23 years. Maternal birthweight, weight and length for age Z-score at 20 months of age were positively associated with next-generation birthweight, whereas paternal variables were not related to the outcome. Conditional growth modelling analyses showed that women whose weight gain in the first 20 months of life was faster than predicted had heavier babies, whereas paternal weight gain was not associated. The association was strongest for mothers whose birthweight for gestational age was in the lowest tertile. Conclusion Maternal, but not paternal birthweight and weight gain in early childhood are positively associated with next-generation birthweight.
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