A novelty seeking phenotype is related to chronic hypothalamic-pituitary-adrenal activity reflected by hair cortisol.
A novelty seeking phenotype is related to chronic hypothalamic-pituitary-adrenal activity reflected by hair cortisol.
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DOI：
10.1016/j.physbeh.2011.03.003
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发表时间：
2011-08-03
影响因子：
2.9
通讯作者：
Fairbanks, Lynn A.
中科院分区：
文献类型：
--
作者：
Laudenslager, Mark L.;Jorgensen, Matthew J.;Grzywa, Rachel;Fairbanks, Lynn A.
关键词：
下丘脑垂体肾上腺（HPA）活动减少与人类更大的新奇寻求有关。头发皮质醇代表了一个综合的替代措施，总皮质醇生产/释放在一段较长的时间内，可能是一个有价值的工具，用于跟踪HPA系统。社会圈养的非人灵长类动物的采样方法（血液，唾液，尿液或粪便的收集）提出了一些技术挑战，特别是当重复采样是必要的。在这里，我们描述了皮质醇水平之间的关系，从230个社会圈养的女性长尾猴（Chlorocebus aethiops sabaeus）和自由选择的新奇寻求表型收集的头发测量。将捕食者样物体放置在室外围栏的外围30 min，并对接近速度（1 m内接近的潜伏期）和兴趣持续性（1 m内1 min间隔的数量）进行评分。结合这两项指标，计算复合新奇寻求评分。跨年的两个不同对象的类内相关系数（ICC= 0.68）表明，这个分数反映了气质的稳定方面。在第二次评估后约3-6个月从每个受试者收集毛发样品;从毛发中测定皮质醇水平。注意到新奇寻求得分与头发皮质醇水平显著负相关（p <0.01）。高头发皮质醇组的新奇寻求分数显著低于低皮质醇组（p <0.05）。这些结果表明，低平均水平的皮质醇促进新奇寻求，而高平均水平抑制新奇寻求行为。
Reduced hypothalamic pituitary adrenal (HPA) activity is associated with greater novelty seeking in humans. Hair cortisol represents an integrated proxy measure of total cortisol production/release over an extended period of time and may be a valuable tool for tracking the HPA system. Sampling approaches (collection of blood, saliva, urine, or feces) for socially housed nonhuman primates present a number of technical challenges for collection particularly when repeated sampling is necessary. Herein we describe a relationship between cortisol levels measured in hair collected from 230 socially housed female vervet (Chlorocebus aethiops sabaeus) monkeys and a free-choice novelty seeking phenotype. A predator-like object was placed at the periphery of the outdoor enclosures for 30 min and speed of approach (latency to approach within 1 m) and persistence of interest (number of 1 min intervals within 1 m) were scored. A composite Novelty Seeking score, combining these two measures, was calculated. The intra-class correlation coefficient (ICC=.68) for two different objects across years indicated that this score reflects a stable aspect of temperament. Hair samples were collected from each subject approximately 3–6 months following the second assessment; cortisol levels were determined from the hair. A significant inverse relationship of Novelty Seeking score with hair cortisol level (p < .01) was noted. The high hair cortisol groups had significantly lower Novelty Seeking scores than the low cortisol groups both years (p’s < .05). These results suggest that low average cortisol levels promote novelty seeking, while high average levels inhibit novelty seeking behavior.
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影响因子：
2.2
作者：
Laudenslager, Mark L.;Natvig, C.;Mikulich-Gilbertson, S. M.;Blevins, M.;Corcoran, C.;Pierre, P. J.;Bennett, A. J.
通讯作者：
Bennett, A. J.
影响因子：
2.2
作者：
Gow, R.;Thomson, S.;Koren, G.
通讯作者：
Koren, G.
DOI：
10.1073/pnas.0707640104
发表时间：
2007-10-02
影响因子：
11.1
作者：
Freimer, Nelson B.;Service, Susan K.;Fairbanks, Lynn A.
通讯作者：
Fairbanks, Lynn A.
影响因子：
2.2
作者：
FAIRBANKS, LA;MCGUIRE, MT
通讯作者：
MCGUIRE, MT
影响因子：
2.9
作者：
D'Anna-Hernandez, Kimberly L.;Ross, Randal G.;Laudenslager, Mark L.
通讯作者：
Laudenslager, Mark L.