No association of ZNF804A rs1344706 with white matter integrity in schizophrenia: a tract-based spatial statistics study.
No association of ZNF804A rs1344706 with white matter integrity in schizophrenia: a tract-based spatial statistics study.
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ZNF804A rs1344706 与精神分裂症白质完整性无关：基于束的空间统计研究
DOI：
10.1016/j.neulet.2012.10.062
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发表时间：
2013-01-04
影响因子：
2.5
通讯作者：
Zhao J
中科院分区：
文献类型：
--
作者：
Wei Q;Kang Z;Diao F;Guidon A;Wu X;Zheng L;Li L;Guo X;Hu M;Zhang J;Liu C;Zhao J
大脑连通性改变被广泛认为是精神分裂症的遗传风险机制。在迄今发现的许多易感基因中，ZNF804A(Rs1344706)是第一个在全基因组水平上与精神分裂症相关的常见遗传变异。先前的功能磁共振研究发现，rs1344706的携带者表现出功能连接的改变。然而，ZNF804A与精神分裂症患者脑白质结构连接的关系仍不清楚。在这项研究中，对100例精神分裂症患者和69名健康对照进行了单核苷酸多态rs1344706的基因分型。进行弥散张量成像(DTI)，并进行基于区域的空间统计学分析。对包括分数各向异性、轴向扩散系数、径向扩散系数和平均扩散系数在内的多种扩散指标进行了系统的统计分析。非配对两样本t检验显示，精神分裂症组和对照组在分数各向异性和扩散率方面存在显著差异。采用双因素方差分析评价ZNF804A对精神分裂症的主效作用及其相互作用。虽然精神分裂症的诊断主要影响辐射扩散率，但在整个受试组或选定的年龄匹配受试组(n=72)中，ZNF804A(Rs1344706)与白质连接性之间没有发现关联。
Altered brain connectivity has been widely considered as a genetic risk mechanism for schizophrenia. Of the many susceptibility genes identified so far, ZNF804A (rs1344706) is the first common genetic variant associated with schizophrenia on a genome-wide level. Previous fMRI studies have found that carriers of rs1344706 exhibit altered functional connectivity. However, the relationship between ZNF804A and white matter structural connectivity in patients of schizophrenia remains unknown. In this study, 100 patients with schizophrenia and 69 healthy controls were genotyped at the single nucleotide polymorphism rs1344706. Diffusion tensor imaging (DTI) was conducted and analyzed with tract-based spatial statistics. Systematic statistical analysis was conducted on multiple diffusion indices, including fractional anisotropy, axial diffusivity, radial diffusivity, and mean diffusivity. Unpaired two-sample t-test revealed significant differences in fractional anisotropy and diffusivity between schizophrenia and control groups. A two-way ANOVA analysis was conducted to assess the main effects of and the interaction between schizophrenia and ZNF804A. Although significant main effects of the diagnosis of schizophrenia were found on radial diffusivity, no association between the ZNF804A (rs1344706) and white matter connectivity was found in the entire group of subjects or in a selected subgroup of age-matched subjects (n = 72).
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影响因子：
30.8
作者：
Xu, Bin;Roos, J. Louw;Karayiorgou, Maria
通讯作者：
Karayiorgou, Maria
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作者：
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通讯作者：
Neale, MC
影响因子：
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作者：
Donohoe, Gary;Morris, Derek W.;Corvin, Aiden
通讯作者：
Corvin, Aiden