Neurodevelopment of children exposed in utero to treatment of maternal malignancy.
Neurodevelopment of children exposed in utero to treatment of maternal malignancy.
复制标题
DOI：
10.1054/bjoc.2001.2090
复制
发表时间：
2001-11-30
影响因子：
8.8
通讯作者：
Koren G
中科院分区：
文献类型：
--
作者：
Nulman I;Laslo D;Fried S;Uleryk E;Lishner M;Koren G
癌症是育龄期第二大常见的死亡原因，约1/1000的妊娠并发症。由于妇女倾向于推迟生育，怀孕期间癌症的发生率可能会增加。改进的恶性肿瘤诊断技术增加了怀孕期间癌症的检测。妊娠期间的恶性疾病被认为与围产期和胎儿结局不良的增加有关，这些不良结局通常是由于母体治疗造成的。医生应该权衡治疗的好处和胎儿暴露的风险。到目前为止，大多数报告都集中在形态学观察非常接近交付的时间与儿童的长期神经发育在子宫内暴露于恶性肿瘤和治疗收集的数据很少。由于大脑在整个怀孕期间和出生后的早期都有分化，即使在头三个月暴露后也可能发生损伤。治疗对儿童的神经、智力和行为功能可能产生的延迟影响从未得到系统的评估。本报告的目的是将所有相关问题总结为一个综述，以便于从业人员和患者获得有关胎儿风险和安全的已知数据。© 2001年癌症研究运动http://www.bjcancer.com
Cancer is the second most common cause of death during the reproductive years, complicating approximately 1/1000 pregnancies. The occurrence of cancer during gestation is likely to increase as a result of a woman's tendency to delay childbearing. Improved diagnostic techniques for malignancies increases detection of cancer during pregnancy. Malignant conditions during gestation are believed to be associated with an increase in poor perinatal and fetal outcomes that are often due to maternal treatment. Physicians should weigh the benefits of treatment against the risks of fetal exposure. To date, most reports have focused on morphologic observations made very close to the time of delivery with little data collected on children's long-term neurodevelopment following in utero exposure to malignancy and treatment. Because the brain differentiates throughout pregnancy and in early postnatal life, damage may occur even after first trimester exposure. The possible delayed effects of treatment on a child's neurological, intellectual and behavioural functioning have never been systematically evaluated. The goal of this report was to summarize all related issues into one review to facilitate both practitioners' and patients' access to known data on fetal risks and safety. © 2001 Cancer Research Campaign http://www.bjcancer.com
登录
查看更多内容
DOI：
10.1016/s0002-9378(99)70160-2
发表时间：
1999-01-01
影响因子：
9.8
作者：
French, NP;Hagan, R;Newnham, JP
通讯作者：
Newnham, JP
DOI：
10.1016/0002-9378(79)90474-5
发表时间：
1979-01-01
影响因子：
9.8
作者：
GRANROTH, G
通讯作者：
GRANROTH, G
DOI：
10.1002/tera.1420410608
发表时间：
1990-06-01
期刊：
TERATOLOGY
影响因子：
--
作者：
KALLEN, B;MAZZE, RI
通讯作者：
MAZZE, RI
影响因子：
5.9
作者：
BLATT, J;MULVIHILL, JJ;POPLACK, DG
通讯作者：
POPLACK, DG
影响因子：
10.4
作者：
HOEL, DG
通讯作者：
HOEL, DG