Umbilical Artery Lactate Correlates with Brain Lactate in Term Infants.
Umbilical Artery Lactate Correlates with Brain Lactate in Term Infants.
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DOI：
10.1055/s-0036-1593844
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发表时间：
2017-05
影响因子：
2
通讯作者：
Mathur AM
中科院分区：
文献类型：
--
作者：
Cahill AG;Macones GA;Smyser CD;López JD;Inder TE;Mathur AM
本研究的目的是确定非异常足月婴儿脐动脉乳酸与脑乳酸之间的相关性。我们在一个持续的前瞻性队列中进行了一项巢式病例对照研究，该队列包含 8,000 多名连续单胎足月（≥ 37 周）非异常婴儿。新生儿在出生后 72 小时内接受脑磁共振成像 (MRI)。病例（脐动脉 pH ≤ 7.10）与对照组（脐动脉 pH > 7.20）的性别和种族按 1:3 匹配。使用西门子软件（德克萨斯州普莱诺）计算用于归一化的单体素磁共振波谱（MRS）、乳酸和N-乙酰天冬氨酸（NAA）。线性回归估计了脐动脉乳酸和脑乳酸增量变化之间的关联，包括直接关联和与 NAA 的比率。在 175 名接受 MRI 和光谱测序的婴儿中，有 52 名婴儿可检测到脑乳酸。 52名出现脑乳酸峰值的婴儿的脐动脉乳酸值为1.6至11.4 mmol/L。脐动脉乳酸每增加 1.0 mmol/L，脑乳酸就会增加 0.02，即使对 NAA 进行校正后，该值仍然显着。 MRS 测量的脑乳酸与非异常足月婴儿的脐动脉乳酸显着相关，这可能有助于解释观察到的脐动脉乳酸与神经系统发病率之间的关联。
The objective of this study was to determine the correlation between umbilical artery lactate with brain lactate in nonanomalous term infants. We performed a nested case–control study within an on-going prospective cohort of more than 8,000 consecutive singleton term (≥ 37 weeks) nonanomalous infants. Neonates underwent cerebral magnetic resonance imaging (MRI) within the first 72 hours of life. Cases (umbilical artery pH ≤ 7.10) were gender and race matched 1:3 to controls (umbilical artery pH > 7.20). Single voxel magnetic resonance spectroscopy (MRS), lactate, and N-acetyl aspartate (NAA) for normalization were calculated using Siemens software (Plano, TX). Linear regression estimated the association between incremental change in umbilical artery lactate and brain lactate, both directly and as a ratio with NAA. Of 175 infants who underwent MRI with spectral sequencing, 52 infants had detectable brain lactate. The 52 infants with brain lactate peaks had umbilical artery lactate values of 1.6 to 11.4 mmol/L. For every 1.0 mmol/L increase in umbilical artery lactate, there was an increase in brain lactate of 0.02, which remained significant even when corrected for NAA. MRS measured brain lactate is significantly correlated with umbilical artery lactate in nonanomalous term infants, which may help explain the observed association between umbilical artery lactate and neurologic morbidity.
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DOI：
10.3109/00016349.2010.513426
发表时间：
2010-10-01
影响因子：
4.3
作者：
Wiberg, Nana;Kallen, Karin;Olofsson, Per
通讯作者：
Olofsson, Per
影响因子：
2.1
作者：
Gunn AJ;Bennet L
通讯作者：
Bennet L
DOI：
10.1080/02841850802334224
发表时间：
2008-11
期刊：
Acta radiologica (Stockholm, Sweden : 1987)
影响因子：
--
作者：
Munkeby BH;De Lange C;Emblem KE;Bjørnerud A;Kro GA;Andresen J;Winther-Larssen EH;Løberg EM;Hald JK
通讯作者：
Hald JK
影响因子：
8
作者：
Thayyil, Sudhin;Chandrasekaran, Manigandan;Robertson, Nicola J.
通讯作者：
Robertson, Nicola J.
影响因子：
3.3
作者：
Nelson, SJ
通讯作者：
Nelson, SJ