Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus.
Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus.
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2 型糖尿病病程中眼表损伤的评估
DOI：
10.1155/2018/1206808
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发表时间：
2018
影响因子：
1.9
通讯作者：
Fu Y
中科院分区：
文献类型：
--
作者：
He F;Zhao Z;Liu Y;Lu L;Fu Y
目的：探讨2型糖尿病病程对眼表的影响，并与非糖尿病对照组进行比较。将120例糖尿病患者按病程分为3组：5年以下组、5~10年组和10年以上组。所有患者均使用角膜地形图仪(Oculus 5M)进行成像。泪膜测量和泪膜描记也被记录下来。额叶腺变化评分为0~6分(MeiBoscore)。10年以上糖尿病组无创首次分手时间(NIKBUT-First)和平均无创分手时间(NIKBUT-Avg)明显短于对照组(P=0.0056 和 P=0.010)。糖尿病10年以上组泪液半月板高度明显低于对照组(P=0.0016)和5年组(P=0.0061)。10年以上糖尿病组的球部和角膜缘充血明显多于对照组(球部充血：P=0.049；角膜缘充血：P=0.026)。糖尿病病程10年以上组与其他三组比较差异有统计学意义(P<；0.05)。在10年以上糖尿病组中，球充血与NIKBUT-1呈显著负相关(r=−0.35 和 P<；0.05)。长期2型糖尿病患者的眼表损害比病程较短的患者更严重。
To investigate the impact of disease duration on the ocular surface during the course of type 2 diabetes mellitus compared with nondiabetic controls. One hundred twenty diabetic patients were divided into three groups according to disease duration: less than 5 years, 5–10 years, and over 10 years. All eyes were imaged using a corneal topographer (Oculus Keratograph 5M). Tear film measurements and meibography were also recorded. Meibomian gland changes were scored from 0 to 6 (meiboscore). The noninvasive breakup time first (NIKBUT-1st) and noninvasive breakup time average (NIKBUT-avg) were significantly shorter in the over 10 years diabetic group compared with the control group (P=0.0056 and P=0.010, resp.). Tear meniscus height (TMH) was significantly lower in the over 10 years diabetic group compared with the control group (P=0.0016) and the 5 years group (P=0.0061). We also found that more patients in the over 10 years diabetic group showed bulbar and limbal hyperemia compared with the control group (bulbar hyperemia: P=0.049; limbal hyperemia: P=0.026). The meiboscore in the over 10 years diabetic group was significantly higher compared with the other three groups (P < 0.05). Bulbar hyperemia showed a significant negative correlation with NIKBUT-1st in the over 10 years diabetic group (r=−0.35 and P < 0.05). Ocular surface damage in long-term type 2 diabetes is more severe than that in patients with shorter disease duration.
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影响因子：
2
作者：
Manaviat MR;Rashidi M;Afkhami-Ardekani M;Shoja MR
通讯作者：
Shoja MR
DOI：
10.1007/s00417-010-1396-8
发表时间：
2010-09-01
影响因子：
2.7
作者：
Messmer, Elisabeth M.;Schmid-Tannwald, Christoph;Kampik, Anselm
通讯作者：
Kampik, Anselm
影响因子：
4.4
作者：
Ding, Juan;Liu, Yang;Sullivan, David A.
通讯作者：
Sullivan, David A.
影响因子：
6.4
作者：
Suzuki, Tomo;Teramukai, Satoshi;Kinoshita, Shigeru
通讯作者：
Kinoshita, Shigeru
影响因子：
4.1
作者：
Goebbels, M
通讯作者：
Goebbels, M