Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms.
Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms.
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DOI：
10.1111/j.1528-1167.2010.02623.x
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发表时间：
2010-07
期刊：
影响因子：
5.6
通讯作者：
Mazarati AM
中科院分区：
文献类型：
--
作者：
Pineda E;Shin D;Sankar R;Mazarati AM
抑郁症是颞叶癫痫（TLE）最常见的合并症之一，对颞叶癫痫患者的生活质量有着深远的负面影响。然而，TLE患者抑郁的原因和机制仍然知之甚少，缺乏有效的治疗方法。我们研究了一种常用的大鼠TLE模型是否可以作为癫痫和抑郁症共病的模型，适用于机制研究和基于机制的抗抑郁治疗的发展。我们发现，服用LiCl和匹罗卡平后癫痫持续状态（SE）并发生自发性复发性癫痫发作的动物，表现出与抑郁状态一致的一系列损伤：行为等效的快感缺乏和绝望；下丘脑-垂体-肾上腺皮质轴（HPA）失调；脑海马血清素传递受损。药理学研究表明，SE后抑郁障碍的发展是海马中白细胞介素-1β信号增强的结果，该信号通过诱导HPA轴的扰动和随后的rape -海马血清素能传递的缺陷导致抑郁。
Depression represents one of the most common comorbidities of temporal lobe epilepsy (TLE), and has profound negative impact on the quality of life of TLE patients. However, causes and mechanisms of depression in TLE remain poorly understood, and its effective therapies are lacking. We examined whether a commonly used model of TLE in rats can be used as a model of comorbidity between epilepsy and depression suitable for both mechanistic studies and for the development mechanism-based antidepressant therapies. We established that animals which had been subjected to LiCl and pilocarpine status epilepticus (SE) and developed spontaneous recurrent seizures, exhibited set of impairments congruent with depressive state: behavioral equivalents of anhedonia and despair; dysregulation of the hypothalamo-pituitary adrenocortical (HPA) axis; compromised raphe-hippocampal serotonergic transmission. Pharmacological studies suggested that depressive impairments following SE develop as a result of the enhanced interleukin-1β signaling in the hippocampus, which leads to depression via inducing perturbations in the HPA axis and subsequent deficit in the raphe-hippocampal serotonergic transmission.
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实验性颞叶癫痫中血浆皮质酮水平升高和抑郁行为。
影响因子：
6.1
作者：
Mazarati AM;Shin D;Kwon YS;Bragin A;Pineda E;Tio D;Taylor AN;Sankar R
通讯作者：
Sankar R
影响因子：
2.6
作者：
Mazarati, Andrey;Shin, Don;Sankar, Raman
通讯作者：
Sankar, Raman
影响因子：
9.9
作者：
Spencer, SS;Berg, AT;Frobish, D
通讯作者：
Frobish, D
影响因子：
9.9
作者：
Gilliam, F. G.;Maton, B. M.;Kuzniecky, R. I.
通讯作者：
Kuzniecky, R. I.
影响因子：
10.6
作者：
Kanner, AM
通讯作者：
Kanner, AM