Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults.
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults.
复制标题
DOI：
10.1038/nature25975
复制
发表时间：
2018-03-15
期刊：
影响因子：
64.8
通讯作者：
Alvarez-Buylla A
中科院分区：
文献类型：
--
作者：
Sorrells SF;Paredes MF;Cebrian-Silla A;Sandoval K;Qi D;Kelley KW;James D;Mayer S;Chang J;Auguste KI;Chang EF;Gutierrez AJ;Kriegstein AR;Mathern GW;Oldham MC;Huang EJ;Garcia-Verdugo JM;Yang Z;Alvarez-Buylla A
成年哺乳动物海马齿状回（DG）颗粒下区（SGZ）不断有新的神经元生成。这一过程与学习和记忆、压力和锻炼有关，并被认为在神经系统疾病中会发生改变。在人类中，一些研究表明，每天都有数百个新的神经元添加到成年DG中，而其他研究发现推定的新神经元要少得多。尽管存在这些差异，但人们普遍认为成年人海马体继续产生新的神经元。在这里，我们表明，一个明确的祖细胞群体不合并在SGZ在人类胎儿或出生后的发展。我们还发现，在DG增殖的祖细胞和年轻的神经元急剧下降，在生命的第一年，只有少数孤立的年轻神经元观察到7和13岁。在成人正常和癫痫患者（18-77岁; n=17尸检; n=12癫痫），年轻的神经元中未检测到DG。猴子（M）mulatta）海马，增殖SGZ存在于出生后的早期生活，但减少在青少年发展的神经发生下降。我们的结论是，年轻的神经元的灵长类动物海马的招聘迅速下降，在生命的第一年，DG神经发生不继续，或者是非常罕见的，在成年人。海马神经发生的早期衰退提出了一个问题，即人类和其他物种之间齿状回的功能有何不同，而成年海马神经发生是保留的。
New neurons continue to be born in the subgranular zone (SGZ) in the dentate gyrus (DG) of the adult mammalian hippocampus. This process has been linked to learning and memory, stress and exercise, and is thought to be altered in neurological disease. In humans, some studies suggest that hundreds of new neurons are added to the adult DG every day, while other studies find many fewer putative new neurons. Despite these discrepancies, it is generally believed that the adult human hippocampus continues to generate new neurons. Here we show that a defined population of progenitor cells does not coalesce in the SGZ during human fetal or postnatal development. We also find that proliferating progenitors and young neurons in the DG sharply decline in the first year of life and only a few isolated young neurons are observed by 7 and 13 years of age. In adult normal and epileptic patients(18–77 years; n=17 postmortem; n=12 epilepsy), young neurons were not detected in the DG. In the monkey (M. mulatta) hippocampus, a proliferative SGZ was present in early postnatal life, but diminished during juvenile development as neurogenesis declined. We conclude that recruitment of young neurons to the primate hippocampus declines rapidly during the first years of life, and that DG neurogenesis does not continue, or is extremely rare, in the adult human. The early decline in hippocampal neurogenesis raises questions about how the function of the dentate gyrus differs between humans and other species in which adult hippocampal neurogenesis is preserved.
登录
查看更多内容
影响因子：
82.9
作者：
Eriksson, PS;Perfilieva, E;Gage, FH
通讯作者：
Gage, FH
成年人类海马神经发生的动力学。
影响因子：
64.5
作者：
Spalding KL;Bergmann O;Alkass K;Bernard S;Salehpour M;Huttner HB;Boström E;Westerlund I;Vial C;Buchholz BA;Possnert G;Mash DC;Druid H;Frisén J
通讯作者：
Frisén J
DOI：
10.1073/pnas.96.10.5768
发表时间：
1999-05-11
影响因子：
11.1
作者：
Kornack, DR;Rakic, P
通讯作者：
Rakic, P
影响因子：
2.5
作者：
ALTMAN, J;BAYER, SA
通讯作者：
BAYER, SA
影响因子：
2.5
作者：
Komitova, M;Eriksson, PS
通讯作者：
Eriksson, PS