The association between conduct problems and the initiation and progression of marijuana use during adolescence: a genetic analysis across time.
The association between conduct problems and the initiation and progression of marijuana use during adolescence: a genetic analysis across time.
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DOI：
10.1007/s10519-006-9124-1
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发表时间：
2007-03
影响因子：
2.6
通讯作者：
van den Bree, Marianne
中科院分区：
文献类型：
--
作者：
Shelton, Katherine;Lifford, Kate;Fowler, Tom;Rice, Frances;Neale, Mike;Harold, Gordon;Thapar, Anita;van den Bree, Marianne
本研究采用前瞻性，纵向设计，调查遗传和环境的影响，早期的行为问题之间的关联，并在青春期大麻使用的启动和进展。父母和老师报告的行为问题，在时间1（1996年）和自我报告的大麻使用评估时间2（2004年），可用于1088青少年双胞胎对参加卡迪夫研究的所有威尔士和英格兰西北部的双胞胎（CaStANET）。使用一种新的方法来建模物质使用的启动和进展维度，研究结果表明，青少年大麻使用的启动受到遗传，共同和独特的环境因素的影响。大麻使用的进展（或频率）受到遗传和独特环境因素的影响。行为问题的调查结果表明，虽然存在或不存在的行为问题在很大程度上是遗传的，相对严重的行为问题似乎更强烈的环境影响。多变量模型拟合表明，儿童和青少年早期的行为问题对8年后使用大麻的风险有很小但很重要的贡献。
The present study used a prospective, longitudinal design to investigate genetic and environmental influences on the association between earlier conduct problems and the initiation and progression of marijuana use during adolescence. Parent- and teacher-reported conduct problems assessed at Time 1 (1996) and self-reported marijuana use assessed at Time 2 (2004) were available for 1088 adolescent twin pairs participating in the Cardiff Study of All Wales and North West of England Twins (CaStANET). Using a novel approach to the modeling of initiation and progression dimensions in substance use, findings suggested that the initiation of marijuana use in adolescence was influenced by genetic, common and unique environmental factors. The progression (or frequency) of marijuana use was influenced by genetic and unique environmental factors. Findings for conduct problems indicated that while the presence or absence of conduct problems was largely heritable, the relative severity of conduct problems appeared to be more strongly environmentally influenced. Multivariate model fitting indicated that conduct problems in childhood and early adolescence made a small but significant contribution to the risk for marijuana use 8 years later.
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影响因子：
2.6
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