BioCycle study: design of the longitudinal study of the oxidative stress and hormone variation during the menstrual cycle.
BioCycle study: design of the longitudinal study of the oxidative stress and hormone variation during the menstrual cycle.
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DOI：
10.1111/j.1365-3016.2008.00985.x
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发表时间：
2009-03
影响因子：
2.8
通讯作者：
BioCycle Study Group
中科院分区：
文献类型：
--
作者：
Wactawski-Wende J;Schisterman EF;Hovey KM;Howards PP;Browne RW;Hediger M;Liu A;Trevisan M;BioCycle Study Group
对人类和动物物种的研究表明，氧化应激可能与健康结果有关，包括男性和女性不孕的风险。性激素已被证明具有抗氧化特性。研究氧化应激在女性中的作用的困难部分是由于这些内源性激素在月经周期中的波动。本研究的目的是确定绝经前女性前瞻性队列在整个月经周期中氧化应激水平与内源性生殖激素水平和抗氧化剂（包括维生素水平）的相关性。目标是招募250名健康、定期绝经的绝经前妇女，持续两个月经周期。参与者每个周期访问诊所多达8次，此时收集血液和尿液。这些访问发生在月经周期的关键阶段，并借助基于周期长度和生育监测数据的算法。此外，参与者还接受了标准化问卷调查，采取了各种身体措施，并收集了其他相关数据。共有259名妇女参加了这项研究，其中250人完成了两个周期，尽管参与者必须遵守严格的研究方案。本报告描述了BioCycle研究的研究设计、基线特征和访视完成率。
Studies in both human and animal species have suggested that oxidative stress may be associated with health outcomes, including the risk of infertility in both males and females. Sex hormones have been shown to have antioxidant properties. The difficulty in studying the role of oxidative stress in females is partly due to fluctuation in these endogenous sex hormones across the menstrual cycle. The aim of this study was to determine the association of oxidative stress levels with endogenous reproductive hormone levels and antioxidants, including vitamin levels, across the menstrual cycle in a prospective cohort of premenopausal women. The goal was to enrol 250 healthy, regularly menstruating premenopausal women for two menstrual cycles. Participants visited the clinic up to 8 times per cycle, at which time blood and urine were collected. The visits occurred at key hormonally defined phases of the menstrual cycle, with the help of an algorithm based on cycle length and data from a fertility monitor. In addition, participants were administered standardised questionnaires, had various physical measures taken, and had other pertinent data collected. A total of 259 women were enrolled in this study, with 250 completing two cycles, despite a demanding study protocol which participants were required to follow. This report describes the study design, baseline characteristics and visit completion rate for the BioCycle study.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
5
作者：
Trevisan, M;Browne, R;Armstrong, D
通讯作者：
Armstrong, D
影响因子：
5
作者：
Block, G;Dietrich, M;Packer, L
通讯作者：
Packer, L
影响因子：
6.1
作者：
Behre, HM;Kuhlage, J;Nieschlag, E
通讯作者：
Nieschlag, E
影响因子：
1.2
作者：
RADLOFF L S
通讯作者：
RADLOFF L S