Transgenerational effects of social stress on social behavior, corticosterone, oxytocin, and prolactin in rats.
Transgenerational effects of social stress on social behavior, corticosterone, oxytocin, and prolactin in rats.
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DOI：
10.1016/j.yhbeh.2014.03.005
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发表时间：
2014-04
影响因子：
3.5
通讯作者：
Nephew, Benjamin C.
中科院分区：
文献类型：
--
作者：
Babb, Jessica A.;Carini, Lindsay M.;Spears, Stella L.;Nephew, Benjamin C.
关键词：
抑郁的产妇护理和家庭冲突等社会压力是巨大的挑战，可对后代和子孙后代产生长期的生理和行为影响。目前的研究调查了一种与行为学相关的慢性社会压力对幼年和成年大鼠的行为和内分泌的跨代影响。在哺乳期间暴露于慢性社会压力会损害F0哺乳母猪的母婴护理，以及那些应激的F0哺乳母猪的F1后代的母爱。总体假设是，应激F1母鼠的雄性和雌性F2后代在青少年和成年时都会表现出减少的社会行为，这些行为影响将伴随着血浆皮质酮、催乳素和催产素的变化。暴露在慢性社会压力下的雌性和雄性F2后代在青少年和成年时都表现出社会行为的减少，这些行为影响伴随着两性皮质酮基础浓度的下降，以及雌性后代幼年催产素和成年催乳素的下降。这些数据支持这样的结论，即社会应激对雌性和雄性后代的社会行为具有代际影响，这种影响是通过下丘脑-垂体-肾上腺轴和下丘脑-垂体-性腺轴的变化来调节的。社会压力模型是研究压力对抑郁症、焦虑症、自闭症和其他涉及被扰乱的社会行为的障碍的行为内分泌学的跨代影响的宝贵资源。
Social stressors such as depressed maternal care and family conflict are robust challenges which can have long-term physiological and behavioral effects on offspring and future generations. The current study investigates the transgenerational effects of an ethologically relevant chronic social stress on the behavior and endocrinology of juvenile and adult rats. Exposure to chronic social stress during lactation impairs maternal care in F0 lactating dams and the maternal care of the F1 offspring of those stressed F0 dams. The overall hypothesis was that the male and female F2 offspring of stressed F1 dams would display decreased social behavior as both juveniles and adults and that these behavioral effects would be accompanied by changes in plasma corticosterone, prolactin, and oxytocin. Both the female and male F2 offspring of dams exposed to chronic social stress displayed decreased social behavior as juveniles and adults, and these behavioral effects were accompanied by decreases in basal concentrations of corticosterone in both sexes, as well as elevated juvenile oxytocin and decreased adult prolactin in the female offspring. The data support the conclusion that social stress has transgenerational effects on the social behavior of the female and male offspring which are mediated by changes in the hypothalamic–pituitary–adrenal axis and hypothalamic–pituitary–gonadal axis. Social stress models are valuable resources in the study of the transgenerational effects of stress on the behavioral endocrinology of disorders such as depression, anxiety, autism, and other disorders involving disrupted social behavior.
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