Hypoglycemia and death in mice following experimental exposure to an extract of Trogia venenata mushrooms.
Hypoglycemia and death in mice following experimental exposure to an extract of Trogia venenata mushrooms.
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DOI：
10.1371/journal.pone.0038712
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Zeng G
中科院分区：
文献类型：
--
作者：
Shi G;He J;Shen T;Fontaine RE;Yang L;Zhou Z;Gao H;Xu Y;Qin C;Yang Z;Liu J;Huang W;Zeng G
在中国云南省发生的一系列不明原因的猝死（SUD）与食用Trogia venenata蘑菇有关。我们评价了这种蘑菇对小鼠的毒性作用。我们制备了新鲜T. venenata和Laccaria vinaceoavellanea蘑菇收集自一个村庄的周围，有SUD。我们将小鼠随机分配到治疗组中，并通过灌胃针以500至3500 mg/kg的剂量范围给予蘑菇提取物和水（对照）。我们在3500 mg/kg剂量给药后7天和500 - 3000 mg/kg剂量给药后24小时观察小鼠死亡率。我们测定了2000 mg/kg剂量后2小时血清中的生化标志物。10只小鼠饲喂T. venenata提取物（3500 mg/kg）在5小时内死亡，而所有对照小鼠（L. vinaceoavellanea提取物和水）在7天的观察期内存活。所有小鼠在暴露于单剂量T后5小时死亡。venenata提取物的剂量范围为1500至3000 mg/kg，而暴露于500 mg/kg剂量的四只小鼠全部存活。小鼠饲喂2000 mg/kg T. venenata提取物在暴露后2小时出现严重低血糖（中位数= 0.66 mmol/L）。 在暴露数小时内的低血糖和死亡，是蘑菇毒性中独特的模式，是T。毒液中毒
Clusters of sudden unexplained death (SUD) in Yunnan Province, China, have been linked to eating Trogia venenata mushrooms. We evaluated the toxic effect of this mushroom on mice. We prepared extracts of fresh T. venenata and Laccaria vinaceoavellanea mushrooms collected from the environs of a village that had SUD. We randomly allocated mice into treatment groups and administered mushroom extracts at doses ranging from 500 to 3500 mg/kg and water (control) via a gavage needle. We observed mice for mortality for 7 days after a 3500 mg/kg dose and for 24 hours after doses from 500 to 3000 mg/kg. We determined biochemical markers from serum two hours after a 2000 mg/kg dose. Ten mice fed T. venenata extract (3500 mg/kg) died by five hours whereas all control mice (L. vinaceoavellanea extract and water) survived the seven-day observation period. All mice died by five hours after exposure to single doses of T. venenata extract ranging from 1500 to 3000 mg/kg, while the four mice exposed to a 500 mg/kg dose all survived. Mice fed 2000 mg/kg of T. venenata extract developed profound hypoglycemia (median = 0.66 mmol/L) two hours after exposure. Hypoglycemia and death within hours of exposure, a pattern unique among mushroom toxicity, characterize T. venenata poisoning.
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影响因子：
2.4
作者：
Yang, Zhu L.;Li, Y. C.;Zeng, G.
通讯作者：
Zeng, G.
蘑菇 Trogia venenata 的天然毒素导致中国云南省突然意外死亡的证据
影响因子：
16.6
作者：
Zhou, Zhong-Yu;Shi, Guo-Qing;Liu, Ji-Kai
通讯作者：
Liu, Ji-Kai
影响因子：
3.7
作者：
Shi GQ;Huang WL;Zhang J;Zhao H;Shen T;Fontaine RE;Yang L;Zhao S;Lu BL;Wang YB;Ma L;Li ZX;Gao Y;Yang ZL;Zeng G
通讯作者：
Zeng G
影响因子：
15.9
作者：
Suh, Sang Won;Gum, Elizabeth T.;Swanson, Raymond A.
通讯作者：
Swanson, Raymond A.
DOI：
10.1097/00004647-200001000-00012
发表时间：
2000-01-01
影响因子：
6.3
作者：
de Courten-Myers, GM;Xi, GH;Myers, RE
通讯作者：
Myers, RE