A case-control study of thallium exposure with the risk of premature ovarian insufficiency in women
A case-control study of thallium exposure with the risk of premature ovarian insufficiency in women
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铊暴露与女性卵巢早衰风险的病例对照研究
DOI：
10.1080/19338244.2021.1931797
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发表时间：
2021-06
影响因子：
1.8
通讯作者：
Liu Jing
中科院分区：
文献类型：
--
作者：
Ma Xiaochen;Pan Wuye;Zhu Zheying;Ye Xiaoqing;Li Chunming;Zhou Jianhong;Liu Jing
摘要铊暴露与女性生殖健康有关，但其与卵巢功能不全（POI）的潜在关系却知之甚少。在这项研究中，共有169例POI患者和209名健康女性从中国浙江省招募。尿铊浓度与POI风险显著正相关[校正比值比（OR）= 1.63，95%CI：1.25-2.13，p < 0.001]，POI病例的几何平均值显著高于肌酐校正值分别为0.213 μg/L、0.302 μg/g，对照组分别为0.153 μg/L、0.233 μg/g。此外，血清促卵泡激素和促黄体生成素水平与尿铊浓度呈正相关，而抗苗勒管激素和雌二醇与铊呈负相关。据我们所知，这是第一项研究提供证据表明，目前环境水平的铊暴露是妇女POI的潜在风险因素。
Abstract Thallium exposure has been associated with female reproductive health, but little is known about its potential association with premature ovarian insufficiency (POI). In this study, a total of 169 patients with POI and 209 healthy women were recruited from Zhejiang province, China. Urinary thallium concentrations were significantly positively associated with the risk of POI [adjusted odds ratio (OR) = 1.63, 95% CI: 1.25–2.13, p < 0.001], geometric mean values of which were significantly higher in POI cases (0.213 μg/L, 0.302 μg/g for creatinine adjustment) than those of controls (0.153 μg/L, 0.233 μg/g for creatinine adjustment). Furthermore, the serum levels of follicle-stimulating hormone and luteinizing hormone were positively associated with urinary thallium concentrations, whereas anti-Mullerian hormone and estradiol were negatively correlated with thallium. To the best of our knowledge, this is the first study to provide evidence that thallium exposure at currently environmental levels is the potential risk factor for POI in women.
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