Adverse childhood experiences interact with inflammation and menopause transition stage to predict verbal memory in women.
Adverse childhood experiences interact with inflammation and menopause transition stage to predict verbal memory in women.
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DOI：
10.1016/j.bbih.2022.100411
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Epperson CN
中科院分区：
文献类型：
--
作者：
Metcalf CA;Johnson RL;Novick AM;Freeman EW;Sammel MD;Anthony LG;Epperson CN
有更多不良童年经历（ACE）的女性在更年期过渡期间可能面临认知问题风险因素的三重威胁：雌二醇减少，炎症增加和早期生活压力后遗症。我们的目的是确定ACE和外周基础炎症标记物与绝经过渡期言语记忆的相关程度。对Penn卵巢老化队列参与者（n = 167）进行ACE评估（低（0-1）或高（≥2）），并在研究结束时对剩余储存的血液样本进行白细胞介素（IL）-6、IL-1-β（IL-1β）、C反应蛋白（CRP）和肿瘤坏死因子α（TNF-α）分析。年度评估包括言语记忆测试（Buschke选择性提醒测试）和绝经期确定。为了估计绝经期、ACE和细胞因子对言语记忆的影响，在广义估计方程中对重复认知结果测量进行建模。协变量包括体重指数、吸烟、种族、教育、基线年龄和基线非文字记忆表现。对细胞因子水平进行对数转换。绝经期越早，即刻言语回忆和延迟言语回忆的成绩越差（p < 0.001）。在围绝经期，较高水平的TNF-α时，较高的ACE暴露与较差的即刻言语回忆相关（斜率差异p = 0.041）。炎症可能机制联系ACE和文字记忆高ACE妇女围绝经期。减少这些人的炎症可能会对更年期过渡期的言语记忆产生积极影响。控制年龄，绝经期的提前与言语记忆的减少有关。在围绝经期，高TNF-α与高ACE女性的言语记忆力下降相关。炎症可能是绝经期高ACE女性容易出现认知缺陷的机制。
Women with more adverse childhood experiences (ACEs) may face a triple threat of risk factors for cognitive concerns during the menopause transition: reduced estradiol, increased inflammation, and early life stress sequelae. Our objective was to determine the extent to which ACEs and peripheral basal inflammatory markers associate with verbal memory across the menopause transition. Penn Ovarian Aging cohort participants (n = 167) were assessed for ACEs (low (0–1) or high (≥2)) and had remaining stored blood samples at study end assayed for interleukin (IL)-6, IL-1-beta (IL-1β), C-reactive protein (CRP), and tumor necrosis factor alpha (TNF-α). Annual assessment included a verbal memory test (the Buschke Selective Reminding Test) and menopause stage determination. To estimate the effects of menopause stage, ACEs, and cytokines on verbal memory, repeated cognitive outcome measures were modeled in generalized estimating equations. Covariates included body mass index, smoking, race, education, age at baseline, and baseline verbal memory performance. Cytokine levels were log-transformed. Advancing menopause stage was associated with worse performance on immediate verbal recall and delayed verbal recall (ps < 0.001). During perimenopause, higher ACE exposure was associated with worse immediate verbal recall at higher levels of TNF-α (slope difference p = 0.041). Inflammation may mechanistically link ACEs and verbal memory for high ACE women during perimenopause. Reducing inflammation for these individuals may have positive impact on verbal memory across the menopause transition. Controlling for age, advancing menopause stage was associated with decrements in verbal memory. In perimenopause, high TNF-α was associated with decreased verbal memory in high ACE women. Inflammation may be a mechanism by which menopausal high ACE women are prone to cognitive deficits.
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影响因子：
5
作者：
Gold, EB;Sternfeld, B;Stellato, R
通讯作者：
Stellato, R
DOI：
10.1097/00042192-200512020-00005
发表时间：
2005-01-01
影响因子：
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影响因子：
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作者：
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