Modulatory role of macrophage migration inhibitory factor on cytokines and clinical features of sarcoidosis.
Modulatory role of macrophage migration inhibitory factor on cytokines and clinical features of sarcoidosis.
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DOI：
10.1038/s41598-022-21212-5
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发表时间：
2022-10-07
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
结节病是一种病因不明的全身性肉芽肿性疾病，在器官表现和临床过程中具有显著的异质性。患有结节病的受试者共有几个特征，例如非坏死性肉芽肿、高丙种球蛋白血症、局部和循环炎性细胞因子增加。巨噬细胞移动抑制因子（MIF）是一种调节细胞功能的多能趋化因子。研究包括健康对照组（n = 28）和结节病患者（n = 65）。收集结节病患者的血清和BAL，并对患者进行3年的纵向随访，记录人口统计学、分期、肺功能检查和器官受累情况。我们检测了结节病患者血清和支气管肺泡灌洗液（BAL）中的MIF，并与临床特征和细胞因子IL-18、IL-10、IL-6、IFN-γ进行了相关性分析。发现血清MIF与IL-10、IFN-γ及%预测肺容量（%TLC）呈正相关。血清IL-18与血清溶菌酶呈显著正相关，与%TLC、%DLCO呈显著负相关。我们确定了两组结节病患者具有不同的临床和细胞因子特征。一组为肺外受累明显，血清MIF、IL-10和IFN-γ水平低的组，一组为血清MIF、IL-10和IFN-γ水平升高的组。我们的工作提供了与结节病细胞因子景观异质性相关的表型多样性的理解。
Sarcoidosis is a systemic granulomatous disease of unknown etiology with significant heterogeneity in organ manifestations and clinical course. Subjects with sarcoidosis share several features such as, non-necrotizing granuloma, hypergammaglobulinemia, increased local and circulating inflammatory cytokines. Macrophage migration inhibitory factor (MIF) is a pluripotent chemokine modulating cellular function. Study included healthy controls (n = 28) and sarcoidosis patients (n = 65). Sera and BAL of sarcoidosis patients were collected and patients were followed longitudinally for 3 years, and demographics, stages, pulmonary function tests, and organ involvements were recorded. We evaluated MIF in the serum and bronchoalveolar lavage (BAL) fluid of sarcoidosis patients in association with clinical features and cytokines, IL-18, IL-10, IL-6, IFN-γ. We found serum MIF had a positive correlation with IL-10 and IFN-γ and % predicted total lung capacity (%TLC). Serum IL-18 had a significant positive correlation with serum lysozyme, but a negative correlation with %TLC and %DLCO. We identified two groups of sarcoidosis subjects with distinct clinical and cytokine features. A group with prominent extrapulmonary involvement, and low serum MIF, IL-10 and IFN-γ and a group with elevated serum MIF, IL-10 and IFN-γ levels. Our work provides understanding of phenotypic diversity in association with heterogeneity in cytokine landscape in sarcoidosis.
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影响因子：
3.7
作者：
Belhomme N;Jouneau S;Bouzillé G;Decaux O;Lederlin M;Guillot S;Perlat A;Jégo P
通讯作者：
Jégo P
影响因子：
1.3
作者：
Iyer SS;Cheng G
通讯作者：
Cheng G
影响因子：
5.6
作者：
Kleemann, R;Kapurniotu, A;Bernhagen, J
通讯作者：
Bernhagen, J
影响因子：
24.3
作者：
Bourbonnais, J. M.;Samavati, I.
通讯作者：
Samavati, I.
DOI：
10.1084/jem.174.5.1049
发表时间：
1991-11-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Keshav S;Chung P;Milon G;Gordon S
通讯作者：
Gordon S