Risk factors for low birth weight and preterm birth: A population-based case-control study in Wuhan, China

Risk factors for low birth weight and preterm birth: A population-based case-control study in Wuhan, China
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低出生体重和早产的危险因素:中国武汉的一项基于人群的病例对照研究

DOI:
10.1007/s11596-017-1729-5
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发表时间:
2017-04
影响因子:
--
通讯作者:
Nie Shao fa
Nie Shao fa
中科院分区:
生物4区
文献类型:
--
作者:
Wang Jing;Zeng Yun;Ni Ze min;Wang Gui;Liu Shu yun;Li Can;Yu Chao li;Wang Qi;Nie Shao fa

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低出生体重(LBW)和早产(PB)与新生儿死亡率和成年期疾病相关。我们于 2011 年 1 月至 2013 年 12 月在中国武汉进行了一项基于人群的病例对照研究,探讨了与 LBW 和 PB 相关的因素。本研究共纳入 337 名 LBW 新生儿、472 名 PB 婴儿以及 708 名正常出生体重和足月妊娠出生的婴儿。新生儿及其父母的信息由训练有素的调查人员通过问卷调查并参考医疗记录来收集。采用逐步选择法的单变量和逻辑回归分析来确定相关因素与LBW和PB的关联。结果显示,孕产妇高血压(OR=6.78,95% CI:2.27~20.29,P=0.001)、孕产妇高危妊娠(OR=1.53,95% CI:1.06~2.21,P=0.022)、孕早期每天水果摄入量≥300 g(OR=1.70,95% CI: 1.17–2.45,P=0.005)与LBW相关。母亲产前BMI≥24 kg/m2(OR=0.48,95% CI:0.32~0.74,P=0.001)和妊娠≥37周(OR=0.01,95% CI:0.00~0.02,P<0.034)是低出生体重的保护因素。产妇高血压(OR=3.36,95% CI:1.26~8.98,P=0.016)、产妇高危妊娠(OR=4.38,95% CI:3.26~5.88,P<0.001)、产妇每天仅进餐两次(OR=1.88,95% CI: 1.10–3.20,P=0.021),并且母亲喜欢含有大量的食物 味精和盐(OR=1.60,95% CI:1.02-2.51,P=0.040)是PB的危险因素。母亲产前BMI≥24 kg/m2(OR=0.66,95% CI:0.47~0.93,P=0.018),房屋距道路距离≥36米(OR=0.72,95% CI:0.53~0.97,P=0.028),居住在农村(OR= 0.60,95% CI: 0.37~0.99,P=0.047)是PB的保护因素。我们的研究揭示了 LBW 和 PB 的一些危险因素和保护因素,为新生儿的疾病预防提供了有价值的信息。
Low birth weight (LBW) and preterm birth (PB) are associated with newborn mortality and diseases in adulthood. We explored factors related to LBW and PB by conducting a population-based case-control study from January 2011 to December 2013 in Wuhan, China. A total of 337 LBW newborn babies, 472 PB babies, and 708 babies with normal birth weights and born from term pregnancies were included in this study. Information of newborns and their parents was collected by trained investigators using questionnaires and referring to medical records. Univariate and logistic regression analyses with the stepwise selection method were used to determine the associations of related factors with LBW and PB. Results showed that maternal hypertension (OR=6.78, 95% CI: 2.27–20.29,P=0.001), maternal high-risk pregnancy (OR=1.53, 95% CI: 1.06–2.21,P=0.022), and maternal fruit intake ≥300 g per day during the first trimester (OR=1.70, 95% CI: 1.17–2.45,P=0.005) were associated with LBW. BMI ≥24 kg/m2of mother prior to delivery (OR=0.48, 95% CI: 0.32–0.74,P=0.001) and gestation ≥37 weeks (OR=0.01, 95% CI: 0.00–0.02,P<0.034) were protective factors for LBW. Maternal hypertension (OR=3.36, 95% CI: 1.26–8.98,P=0.016), maternal high-risk pregnancy (OR=4.38, 95% CI: 3.26–5.88,P<0.001), maternal meal intake of only twice per day (OR=1.88, 95% CI: 1.10–3.20,P=0.021), and mother liking food with lots of aginomoto and salt (OR=1.60, 95% CI: 1.02–2.51,P=0.040) were risk factors for PB. BMI ≥24 kg/m2of mother prior to delivery (OR=0.66, 95% CI: 0.47–0.93,P=0.018), distance of house from road ≥36 meters (OR=0.72, 95% CI: 0.53–0.97,P=0.028), and living in rural area (OR= 0.60, 95% CI: 0.37–0.99,P=0.047) were protective factors for PB. Our study demonstrated some risk factors and protective factors for LBW and PB, and provided valuable information for the prevention of the conditions among newborns.
DOI: 10.1016/s0140-6736(07)61692-4
发表时间: 2008-01-26
期刊: LANCET
影响因子: 168.9
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DOI: --
发表时间: 2015
期刊: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
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