Electroporation of a lipid bilayer as a chemical reaction.
Electroporation of a lipid bilayer as a chemical reaction.
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作为化学反应的脂质双层的电穿孔。
DOI：
10.1002/bem.20060
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Lee,RaphaelC
中科院分区：
文献类型：
--
作者：
Bier,Martin;Gowrishankar,TR;Chen,Wei;Lee,RaphaelC
When a cell's transmembrane potential is increased from a physiological one to more than 370 mV, the transmembrane current increases more than hundredfold within a millisecond. This is due to the formation of conductive pores in the membrane. We construct a model in which we conceive of pore formation as a voltage sensitive chemical reaction. The model predicts the logarithm of the pore formation rate to increase proportionally to the square of the voltage. We measure currents through frog muscle cell membranes under 8 ms pulses of up to 440 mV. The experimental data appear consistent with the model. Bioelectromagnetics 25:634–637, 2004. © 2004 Wiley‐Liss, Inc.
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