Neural population dynamics during reaching.

Neural population dynamics during reaching.
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DOI:
10.1038/nature11129
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发表时间:
2012-07-05
期刊:
影响因子:
64.8
通讯作者:
Shenoy, Krishna V.
Shenoy, Krishna V.
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Churchland, Mark M.;Cunningham, John P.;Kaufman, Matthew T.;Foster, Justin D.;Nuyujukian, Paul;Ryu, Stephen I.;Shenoy, Krishna V.

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大多数运动皮层理论都假设神经活动代表运动参数。这种观点源自初级视觉皮层的类似方法,其中神经活动代表光的模式。但目前还不清楚这个类比是否成立。运动皮层中的单神经元反应显得异常复杂,并且对于表示哪些运动参数存在明显的分歧。更好的类比可能是其他运动系统,其共同原理是有节奏的神经活动。我们发现,伸手过程中运动皮层的反应包含短暂但强烈的振荡成分,这对于非周期性行为来说是非常出乎意料的。振荡幅度和相位自然地从准备状态开始,表明准备神经活动的机械作用。这些结果表明,人群反应的结构出乎意料但令人惊讶地简单。这种基本结构解释了个体神经元反应的许多令人困惑的特征。
Most theories of motor cortex have assumed that neural activity represents movement parameters. This view derives from an analogous approach to primary visual cortex, where neural activity represents patterns of light. Yet it is unclear how well that analogy holds. Single-neuron responses in motor cortex appear strikingly complex, and there is marked disagreement regarding which movement parameters are represented. A better analogy might be with other motor systems, where a common principle is rhythmic neural activity. We found that motor cortex responses during reaching contain a brief but strong oscillatory component, something quite unexpected for a non-periodic behavior. Oscillation amplitude and phase followed naturally from the preparatory state, suggesting a mechanistic role for preparatory neural activity. These results demonstrate unexpected yet surprisingly simple structure in the population response. That underlying structure explains many of the confusing features of individual-neuron responses.
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