Antimüllerian hormone and F2-isoprostanes in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.
Antimüllerian hormone and F2-isoprostanes in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.
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DOI：
10.1016/j.fertnstert.2020.04.028
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发表时间：
2020-09
影响因子：
6.7
通讯作者：
Wellons, Melissa F.
中科院分区：
文献类型：
--
作者：
Kim, Catherine;Slaughter, James C.;Terry, James G.;Jacobs, David R., Jr.;Parikh, Nisha;Appiah, Duke;Leader, Benjamin;Moravek, Molly B.;Wellons, Melissa F.
在以人群为基础的黑人和白人女性队列中，研究系统性氧化应激标志物f2 -异前列腺素是否与卵巢储备指标抗<s:1>勒氏激素（AMH）相关。CARDIA妇女研究是一项基于人群的队列研究，黑人（n=398）和白人（n=432）晚期育龄妇女（平均年龄40±3.6岁），无妇科手术史。在调整年龄、种族、吸烟、体重指数和口服避孕药使用等因素后，线性回归模型评估血浆f2 -异前列腺素是否与对数转化的AMH相关。f2 -异前列腺素水平升高与AMH水平降低相关（β - 0.048 / SD， 95%可信区间为- 0.087,- 0.01）。观察到的相关性在年轻时更强（年龄水平与f2 -异前列腺素之间的相互作用p=0.04）。氧化应激途径中其他步骤的指标（超氧化物歧化酶、对氧磷酶活性、氧化低密度脂蛋白胆固醇和类胡萝卜素）与AMH无关，除了较低的磷脂酶A2活性（β 0.036 / SD, 95% CI 0.001, 0.071）与所有年龄段的较低AMH相关。在一项基于人群的队列研究中，f2 -异前列腺素水平升高与卵巢储备能力降低相关，尤其是在年轻人群中。在基于人群的样本中，较高的f2 -异前列腺素（系统性氧化应激的指标）与较低的AMH相关，特别是在年轻女性中。
To examine whether F2-isoprostanes, a marker of systematic oxidative stress, are associated with anti-Müllerian hormone (AMH), an indicator of ovarian reserve, in a population-based cohort of black and white women. Cross-sectional analysis The CARDIA Women’s Study, a population-based cohort Black (n=398) and white (n=432) late reproductive-age women (mean age 40 ± 3.6 years) without histories of gynecologic surgery. Log-transformed serum AMH concentrations Linear regression models evaluated whether plasma F2-isoprostanes were associated with log-transformed AMH after adjustment for age, race, smoking, body mass index, and oral contraceptive use. Higher levels of F2-isoprostanes were associated with lower AMH levels (β−0.048 per SD, 95% confidence interval −0.087, −0.01). The observed associations were stronger at younger ages (p=0.04 for interaction between levels of age and F2-isoprostanes). Indicators of other steps in the oxidative stress pathway (super-oxide dismutase, paraoxonase activity, oxidized low-density lipoprotein cholesterol, and carotenoids) were not associated with AMH, except lower phospholipase A2 activity (β 0.036 per SD, 95% CI 0.001, 0.071) was associated with lower AMH across all ages. In a population-based cohort, higher levels of F2-isoprostanes were associated with lower ovarian reserve, particularly at younger ages. In a population-based sample, higher F2-isoprostanes, an indicator of systemic oxidative stress, is associated with lower AMH, particularly in younger women.
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影响因子：
13.3
作者：
May-Panloup, Pascale;Boucret, Lisa;Reynier, Pascal
通讯作者：
Reynier, Pascal
影响因子：
6.1
作者：
Depmann, M.;Eijkemans, M. J. C.;Broekmans, F. J. M.
通讯作者：
Broekmans, F. J. M.
DOI：
10.1161/01.atv.0000148322.89911.44
发表时间：
2005-01-01
影响因子：
8.7
作者：
Iribarren, C;Gross, MD;Loria, CM
通讯作者：
Loria, CM
影响因子：
2.1
作者：
Lee, Keane K.;Fortmann, Stephen P.;Iribarren, Carlos
通讯作者：
Iribarren, Carlos
DOI：
10.1097/gme.0b013e3181d20cd2
发表时间：
2010-07
期刊：
Menopause (New York, N.Y.)
影响因子：
--
作者：
Appt SE;Chen H;Goode AK;Hoyer PB;Clarkson TB;Adams MR;Wilson ME;Franke AA;Kaplan JR
通讯作者：
Kaplan JR