On the theory of tumor self-seeding: implications for metastasis progression in humans.
On the theory of tumor self-seeding: implications for metastasis progression in humans.
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DOI:
10.1186/bcr2561
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发表时间:
2010
期刊:
影响因子:
--
通讯作者:
Aguirre-Ghiso JA
中科院分区:
文献类型:
--
作者:
Aguirre-Ghiso JA
Metastasis remains the leading cause of death among cancer patients because few effective treatment options are available. A recent paper proposes a new twist on metastasis. The paper shows that circulating tumor cells can return to the primary tumor, a process termed tumor self-seeding or cross-seeding, and that this helps breeding tumor cells that give rise to aggressive metastatic variants. A viewpoint presented here addresses the implications of these studies for human cancer metastasis.
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