Synovial inflammation in patients with osteonecrosis of the femoral head.
Synovial inflammation in patients with osteonecrosis of the femoral head.
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DOI：
10.1111/j.1752-8062.2009.00133.x
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发表时间：
2009-08
期刊：
影响因子：
--
通讯作者：
Koch AE
中科院分区：
文献类型：
--
作者：
Rabquer BJ;Tan GJ;Shaheen PJ;Haines GK 3rd;Urquhart AG;Koch AE
许多旨在阐明股骨头坏死（ON）发病机制的工作都集中在骨血供方面，很少关注周围的滑膜组织（ST）。我们假设ON患者表现出滑膜炎症。使用免疫组织学技术，我们发现大量ON患者存在滑膜炎症。此外，ON患者群体具有发炎ST，而没有炎性疾病共病。这些患者的炎性浸润主要包括CD4+ T细胞和CD68+巨噬细胞，后者表达的细胞粘附分子水平升高。我们的研究结果表明，存在以前未被识别的ON患者群体，没有诊断的炎症共病和主要由巨噬细胞和CD4+ T细胞浸润组成的高度炎症的滑膜。
Much of the work aimed at elucidating the pathogenesis of osteonecrosis (ON) of the femoral head has focused on bone blood supply, with little attention to the surrounding synovial tissue (ST). We hypothesized that patients with ON exhibit synovial inflammation. Using immunohistological techniques, we found that a large population of patients with ON had synovial inflammation. Moreover, a population of ON patients had inflamed ST without having an inflammatory disease co-morbidity. The inflammatory infiltrate in these patients comprised primarily CD4+ T cells and CD68+ macrophages, the latter of which expressed increased levels of cellular adhesion molecules. Our results suggest the presence of a previously unrecognized population of ON patients without a diagnosed inflammatory co-morbidity and a highly inflammed synovium consisting primarily of a macrophage and CD4+ T-cell infiltrate.
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影响因子：
1.8
作者：
Steinberg, ME;Steinberg, DR
通讯作者：
Steinberg, DR
影响因子：
--
作者：
RANHEIM, EA;KIPPS, TJ
通讯作者：
KIPPS, TJ
影响因子：
5
作者：
Szekanecz, Z;Koch, A E
通讯作者：
Koch, A E
影响因子：
27.4
作者：
Pessler, F.;Dai, L.;Schumacher, H. R.
通讯作者：
Schumacher, H. R.
影响因子：
9.1
作者：
KOCH, AE;ROBINSON, PG;POPE, RM
通讯作者：
POPE, RM