Flow behavior of heavy silicone oil during eye movements.
Flow behavior of heavy silicone oil during eye movements.
复制标题
眼球运动过程中重硅油的流动行为。
DOI：
10.1167/iovs.14-15439
复制
发表时间：
2014
影响因子：
4.4
通讯作者：
Chan YK
中科院分区：
文献类型：
--
作者：
Chan YK
目的：目前，有各种重硅油（HSO）填充剂可用于治疗下方视网膜疾病。这些HSO试剂中的大多数是均质液体或两种组分的混合物。已经报道了它们在体内乳化率的变化。在这项研究中，我们研究了它们在类眼运动期间的流动行为。方法。：驱动填充有各种HSO试剂的模型眼室以进行眼样运动。对5种不同配方的HSO和2种其他填塞剂进行了试验。通过视频记录并分析舱内各种HSO的运动。结果：Oxane HD相对于眼腔的运动和速度大于粘性较低的Densiron 68。Densiron 68的性能与均质HSO 1.07和HSO 1.20相似。Oxane HD和11%二氧化硅流体与其他HSO试剂相比表现出非常不同的行为。此外，11%硅油表现出与低粘度填塞剂F6H8相似的性能。结论：HSO的粘度不是确定HSO在眼球运动期间的行为的唯一参数。通过混合不同类型的基础SO和“重质”添加剂制造的各种HSO显示出不同的流动行为。重质添加剂在基质SO中的溶解度和稳定性在经受眼球运动时改变其流动，这可能有助于体内乳化。
Purpose.: Currently there are various heavy silicone oil (HSO) tamponade agents available for treating inferior retinal diseases. Most of these HSO agents are either homogeneous liquids or a mixture of two components. Variations in their emulsification rates in vivo have been reported. In this study, we investigated their flow behaviors during eye-like movements.Methods.: A model eye chamber filled with various HSO agents was driven to perform eye-like movements. Five types of HSOs with different formulations together with 2 other tamponade agents were tested. Movements of various HSOs inside the chamber were captured by video recording and analyzed.Results.: Oxane HD has a larger movement and higher velocity relative to the eye chamber than the less viscous Densiron 68. The behavior of Densiron 68 is similar to that of homogeneous HSO 1.07 and HSO 1.20. Both Oxane HD and 11% silica fluid show very different behaviors compared to the other HSO agents. In addition, 11% silica fluid shows behavior similar to that of F6H8, a low-viscosity tamponade agent.Conclusions.: The viscosity of HSO is not the sole parameter with which to determine the behavior of HSO during eye movements. Various HSOs that are manufactured by mixing different types of base SO and “heavy” additives show distinct flow behaviors. The solubility and stability of the heavy additives in the base SO alter its flow when subjected to eye movements, which may contribute to in vivo emulsification.
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