Dynamic grouping of hippocampal neural activity during cognitive control of two spatial frames.
Dynamic grouping of hippocampal neural activity during cognitive control of two spatial frames.
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DOI：
10.1371/journal.pbio.1000403
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发表时间：
2010-06-22
期刊：
影响因子：
9.8
通讯作者：
Fenton AA
中科院分区：
文献类型：
--
作者：
Kelemen E;Fenton AA
海马神经元通过瞬时组织成共同活动神经元的亚群来代表两个并发的空间信息流，并且可以在任何给定时间反映最相关的行为信息。认知控制是协调多个信息流以防止混淆并选择适当的行为反应的能力，特别是在面临竞争性选择时。尽管其理论和临床意义，认知控制的神经机制知之甚少。使用两帧位置回避任务和部分海马失活，我们证实，完整的海马功能是必要的协调两个流的空间信息。大鼠被放置在一个连续旋转的竞技场上，并被训练根据两个同时相关的空间框架来组织它们的行为：一个是静止的，另一个是旋转的。然后，我们研究了如何在这两个空间框架的位置信息是组织在动作电位放电的合奏海马细胞。这两个信息流表示在神经元放电的地方细胞活动的组织根据这两个空间框架，但几乎所有的细胞优先表示的位置在两个空间框架之一。在任何给定的时间，大多数共同活动的细胞倾向于在同一空间框架中表示位置，从而降低了两个信息流之间干扰的风险。一个合奏的偏好，以表示在一个或另一个空间框架内交替的会话中的位置，但在每一个时刻，在更行为相关的空间框架中的位置更有可能被表示。这种放电组织成瞬时的共同活动神经元组，这些神经元在25 ms内一起放电，以表示同一空间框架中的位置。这些研究结果表明，动态分组，代表相同的信息流的神经亚群的瞬时共激活，可以协调并发信息流的表示，避免混淆，证明海马体中的认知控制的神经合奏相关。理解世界和做出最佳决策需要使用最相关的信息，同时忽略不相关的信息，这是一种被称为“认知控制”的心理现象。对于同一群神经元如何同时处理多个信息流，人们知之甚少。在这项研究中，我们研究了认知控制的海马神经元网络中已知代表空间的潜在神经机制。我们将电极植入大鼠海马，同时记录多个神经元的动作电位放电。这些记录是在老鼠在旋转圆盘上觅食时进行的，它们使用认知控制来协调来自不同空间框架的空间信息。我们发现，在每一个时刻，放电优先代表的位置在一个或另一个空间框架。重要的是，我们能够影响这些空间帧的行为相关性，并且我们发现放电在一个或其他帧中的信号位置之间交替，雅阁与其当前的行为重要性一致。这些神经元活跃的时间也与它们的功能有关，例如，如果神经元在几十毫秒到几秒内共同活跃，它们就共同代表了同一空间框架中的位置。我们的结论是，认知控制是由一个动态的功能分组。分布在许多神经元上的神经活动通过代表连贯信息流的共同激活瞬时组织成功能组。
Hippocampal neurons represent two concurrent streams of spatial information by transiently organizing into subpopulations of coactive neurons and can reflect the most behaviorally relevant information at any given time. Cognitive control is the ability to coordinate multiple streams of information to prevent confusion and select appropriate behavioral responses, especially when presented with competing alternatives. Despite its theoretical and clinical significance, the neural mechanisms of cognitive control are poorly understood. Using a two-frame place avoidance task and partial hippocampal inactivation, we confirmed that intact hippocampal function is necessary for coordinating two streams of spatial information. Rats were placed on a continuously rotating arena and trained to organize their behavior according to two concurrently relevant spatial frames: one stationary, the other rotating. We then studied how information about locations in these two spatial frames is organized in the action potential discharge of ensembles of hippocampal cells. Both streams of information were represented in neuronal discharge—place cell activity was organized according to both spatial frames, but almost all cells preferentially represented locations in one of the two spatial frames. At any given time, most coactive cells tended to represent locations in the same spatial frame, reducing the risk of interference between the two information streams. An ensemble's preference to represent locations in one or the other spatial frame alternated within a session, but at each moment, location in the more behaviorally relevant spatial frame was more likely to be represented. This discharge organized into transient groups of coactive neurons that fired together within 25 ms to represent locations in the same spatial frame. These findings show that dynamic grouping, the transient coactivation of neural subpopulations that represent the same stream of information, can coordinate representations of concurrent information streams and avoid confusion, demonstrating neural-ensemble correlates of cognitive control in hippocampus. Understanding the world and making optimal decisions requires using the most relevant information while at the same time ignoring irrelevant information, a psychological phenomenon known as “cognitive control.” How the same population of neurons deals with multiple streams of information simultaneously is poorly understood. In this study, we investigated the underlying neural mechanisms of cognitive control in a network of hippocampal neurons known to represent space. We implanted electrodes into the hippocampus of rats and recorded the action potential discharge of many neurons at the same time. The recordings were made while rats that were foraging on a rotating disk used cognitive control to coordinate spatial information from different spatial frames. We found that at each moment, discharge preferentially represented location in one or the other spatial frame. Importantly, we were able to influence the behavioral relevance of these spatial frames, and we found that discharge alternated between signaling location in one or the other frames in accord with its current behavioral importance. The timing of when these neurons were active was also related to their function, such that neurons collectively represented locations in the same spatial frame if they were coactive within a few tens of milliseconds to seconds. We conclude that cognitive control is mediated by a dynamic functional grouping. Neural activity distributed across many neurons transiently organizes into functional groups by coactive firing that represents a coherent stream of information.
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DOI：
10.1523/jneurosci.2862-08.2008
发表时间：
2008-10-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fenton AA;Kao HY;Neymotin SA;Olypher A;Vayntrub Y;Lytton WW;Ludvig N
通讯作者：
Ludvig N
影响因子：
2.5
作者：
Cimadevilla, JM;Fenton, AA;Bures, J
通讯作者：
Bures, J
影响因子：
5.3
作者：
Diba, Kamran;Buzsaki, Gyoergy
通讯作者：
Buzsaki, Gyoergy
影响因子：
2.5
作者：
Brown, JE;Skaggs, WE
通讯作者：
Skaggs, WE
影响因子：
16.2
作者：
Leutgeb, JK;Leutgeb, S;Moser, EI
通讯作者：
Moser, EI