Phthalate exposures and one-year change in body mass index across the menopausal transition.
Phthalate exposures and one-year change in body mass index across the menopausal transition.
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邻苯二甲酸盐暴露与绝经期体重指数的一年变化。
DOI：
10.1016/j.envres.2020.110598
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发表时间：
2021-03
影响因子：
8.3
通讯作者：
Strakovsky RS
中科院分区：
文献类型：
--
作者：
Haggerty DK;Flaws JA;Li Z;Strakovsky RS
更年期是与体重变化相关的荷尔蒙敏感期。邻苯二甲酸酯是一种普遍存在的扰乱内分泌的化学物质，可以破坏体重的动态平衡，但目前尚不清楚这种情况是否发生在更年期过渡期间。我们的目标是(1)确定绝经前和围绝经期妇女的邻苯二甲酸酯暴露是否与体重指数(BMI)一年的变化有关，以及(2)确定这些联系在绝经过渡期间是否有所不同。我们使用了524名参加中年妇女健康研究的参与者的数据来解决我们的目标。我们计算了从基线到大约一年后的第一次随访期间BMI的变化。邻苯二甲酸盐暴露是通过测量在基线的四周期间收集的两到四个现场尿样中的尿代谢物来近似计算的。我们将邻苯二甲酸单(2-乙基己基)酯(∑)、邻苯二甲酸单(2-乙基-5-羟基己基)酯(MEHHP)、邻苯二甲酸单(2-乙基-5-氧基己基)(MEOHP)和邻苯二甲酸单(2-乙基-5-羧基戊基)酯(MECPP)进行摩尔转化和求和，以接近于接触邻苯二甲酸二(2-乙基己基)酯(∑DEHP)、邻苯二甲酸单(3-羧丙基)和邻苯二甲酸单苯甲酯(∑塑料)；以及邻苯二甲酸单乙酯、邻苯二甲酸单丁酯和邻苯二甲酸单异丁酯，以接近个人护理产品(∑PCP)中邻苯二甲酸酯的暴露。我们使用多变量线性回归模型来评估比重调整的邻苯二甲酸盐代谢产物或总和与一年的BMI变化之间的关系，并考虑了从基线到第一次随访期间每个女性的更年期状态变化是否会导致相关性的不同。在基线水平，大多数女性是绝经前(67.8%)、非西班牙裔白人(67.9%)和受过大学教育(65.8%)。总体而言，尿邻苯二甲酸盐代谢物或总和与一年的BMI变化无关。分层分析发现，在从基线到第一次随访从围绝经期过渡到绝经期后的女性中，∑DEHP(及其三种代谢物：MEHP、MEHHP和MEOHP)与一年的体重指数变化呈正相关。例如，在这些女性中，从基线到第一次随访，体重指数每增加一倍，体重指数就增加0.65公斤/平方米(95%可信区间：0.17，1.13)。在从基线到第一次随访的围绝经期妇女中，与个人护理产品相关的邻苯二甲酸盐代谢产物(MBP和MEP)与一年的BMI变化呈负相关，而在从围绝经期过渡到绝经后的妇女中，miBP和MEP与一年的BMI变化呈正相关。我们发现，在从基线到第一次随访从围绝经期过渡到绝经期后的女性中，一些邻苯二甲酸酯与一年的BMI变化之间存在最强的相关性。这支持了先前的证据，即更年期过渡是女性生活中的激素敏感期。为了确定邻苯二甲酸盐暴露是否有助于与更年期转变相关的体重变化，需要更多的研究来证实我们的发现。
The menopausal transition is a hormonally sensitive period associated with changes in body weight. Phthalates are ubiquitous endocrine disrupting chemicals that could disrupt weight homeostasis, but it is unknown whether this occurs during the menopausal transition. Our objectives were to (1) determine if phthalate exposure in pre- and perimenopausal women was associated with one-year change in body mass index (BMI), and (2) determine if these associations differed across the menopausal transition. We addressed our objectives using data from 524 participants enrolled in the Midlife Women’s Health Study. We calculated change in BMI from baseline to first follow-up visit approximately one year later. Phthalate exposures were approximated by measuring urinary metabolites in pools of two-to-four spot urine samples collected across a four-week period at baseline. We molar-converted and summed mono-(2-ethylhexyl) phthalate (mEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (mEHHP), mono(2-ethyl-5-oxohexyl) phthalate (mEOHP), and mono(2-ethyl-5-carboxypentyl) phthalate (mECPP) to approximate exposure to di-(2-ethylhexyl) phthalate (∑DEHP); ∑DEHP, mono(3-carboxypropyl) phthalate (mCPP), and monobenzyl phthalate (mBzP) to approximate exposure to plasticizer phthalates (∑Plastics); and monoethyl phthalate (mEP), monobutyl phthalate (mBP), and monoisobutyl phthalate (miBP) to approximate exposure to phthalates from personal care products (∑PCP). We used multivariable linear regression models to evaluate associations of specific gravity-adjusted ln-transformed phthalate metabolites or sums with one-year BMI change, and also considered whether associations differed depending on each woman’s menopausal status change from baseline to first follow-up. At baseline, most women were premenopausal (67.8%), non-Hispanic white (67.9%), and college educated (65.8%). Overall, urinary phthalate metabolites or sums were not associated with one-year BMI change. Stratified analysis identified positive associations between ∑DEHP (and three of its metabolites: MEHP, MEHHP, and MEOHP) and one-year BMI change among women who transitioned from peri- to post-menopause from baseline to first follow-up. For example, in these women, with each doubling of ∑DEHP, BMI increased by 0.65 kg/m2 (95%CI: 0.17, 1.13) from baseline to first follow-up. Personal care product-associated phthalate metabolites (mBP and mEP) were negatively associated with one-year BMI change among women who remained perimenopausal from baseline to first follow-up, while miBP and mEP were positively associated with one-year BMI change among women who transitioned from peri- to post-menopause. We found the strongest associations between some phthalates and one-year BMI change in women who transitioned from peri- to post-menopause from baseline to first follow-up. This supports previous evidence that the menopausal transition is a hormonally sensitive period in women’s lives. To establish whether phthalate exposure contributes to body weight changes associated with the menopausal transition, substantially more research is needed to corroborate our findings.
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DOI：
10.3109/13697139909038063
发表时间：
1999-09-01
期刊：
Climacteric : the journal of the International Menopause Society
影响因子：
--
作者：
Guthrie, J R;Dennerstein, L;Dudley, E C
通讯作者：
Dudley, E C
影响因子：
5.4
作者：
Hoyt, Lindsay Till;Falconi, April M.
通讯作者：
Falconi, April M.
影响因子：
3.8
作者：
Blair, RM;Fang, H;Sheehan, DM
通讯作者：
Sheehan, DM
影响因子：
3.5
作者：
Engel, Anika;Buhrke, Thorsten;Lampen, Alfonso
通讯作者：
Lampen, Alfonso
影响因子：
5.8
作者：
Lim, Jung-eun;Choi, BongKyoo;Jee, Sun Ha
通讯作者：
Jee, Sun Ha