Epigenetic Regulation of Neuroinflammation in Alzheimer's Disease.
Epigenetic Regulation of Neuroinflammation in Alzheimer's Disease.
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阿尔茨海默病（Alzheimer's disease，AD）是一种慢性进行性神经退行性疾病，临床表现为认知功能减退和行为障碍。近年来，越来越多的研究表明炎症反应在AD的发生发展中起着关键作用，神经炎症被认为是AD的第三大病理驱动因素，仅次于淀粉样蛋白（Aβ）沉积和神经纤维缠结（NFT）。表观遗传机制是指不依赖于DNA序列改变的基因表达的可遗传变化，是神经炎症的重要调节因子，已成为AD的潜在治疗靶点。在转录抑制或激活的调节下，表观遗传修饰谱与中枢神经系统疾病中的炎性基因表达和神经元分化和认知功能的信号通路密切相关。本文综述了AD的表观遗传调控机制，重点介绍了AD炎症基因和信号通路中的DNA和组蛋白修饰，并讨论了AD的抑制剂。
Alzheimer’s disease (AD) is a chronic and progressive neurodegenerative disease and clinically manifests with cognitive decline and behavioral disabilities. Over the past years, mounting studies have demonstrated that the inflammatory response plays a key role in the onset and development of AD, and neuroinflammation has been proposed as the third major pathological driving factor of AD, ranking after the two well-known core pathologies, amyloid β (Aβ) deposits and neurofibrillary tangles (NFTs). Epigenetic mechanisms, referring to heritable changes in gene expression independent of DNA sequence alterations, are crucial regulators of neuroinflammation which have emerged as potential therapeutic targets for AD. Upon regulation of transcriptional repression or activation, epigenetic modification profiles are closely involved in inflammatory gene expression and signaling pathways of neuronal differentiation and cognitive function in central nervous system disorders. In this review, we summarize the current knowledge about epigenetic control mechanisms with a focus on DNA and histone modifications involved in the regulation of inflammatory genes and signaling pathways in AD, and the inhibitors under clinical assessment are also discussed.
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影响因子：
4.8
作者：
Coulter, Jonathan B.;O'Driscoll, Cliona M.;Bressler, Joseph P.
通讯作者：
Bressler, Joseph P.
影响因子：
2.1
作者：
Doroszkiewicz J;Mroczko P;Kulczyńska-Przybik A
通讯作者：
Kulczyńska-Przybik A
影响因子：
--
作者：
Azizi, Gholamreza;Navabi, Shadi S;Mirshafiey, Abbas
通讯作者：
Mirshafiey, Abbas
影响因子：
5.3
作者：
Fakhoury M
通讯作者：
Fakhoury M
DOI：
10.1093/dnares/dst029
发表时间：
2013-12
期刊：
DNA research : an international journal for rapid publication of reports on genes and genomes
影响因子：
--
作者：
Bellizzi D;D'Aquila P;Scafone T;Giordano M;Riso V;Riccio A;Passarino G
通讯作者：
Passarino G