Delayed emergence of behavioral and electrophysiological effects following juvenile ketamine exposure in mice.
Delayed emergence of behavioral and electrophysiological effects following juvenile ketamine exposure in mice.
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DOI：
10.1038/tp.2015.111
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发表时间：
2015-09-15
影响因子：
6.8
通讯作者：
Siegel SJ
中科院分区：
文献类型：
--
作者：
Nagy LR;Featherstone RE;Hahn CG;Siegel SJ
成年期频繁滥用氯胺酮与精神病风险增加以及认知缺陷相关，包括高级执行功能和记忆形成的破坏。尽管氯胺酮的主要滥用者是青少年和年轻人，但很少有研究评估其对青少年认知的影响。因此，本研究分析了青少年氯胺酮暴露对认知发展的影响。4周龄幼鼠经慢性氯胺酮(20 mg kg−1，ip)染毒。每日)，为期14天。小鼠在幼年期(7周龄)和成年鼠(12周龄)暴露后立即进行测试。测试方法包括脑电(EEG)对听觉刺激的反应、社会选择测试和6臂径向水迷宫任务。结果测量包括低频脑电反应、事件相关电位(ERP)幅度、社会行为指数和空间工作记忆指数。青少年接触氯胺酮与成年后的电生理异常有关，特别是在诱导的theta功率和P80事件相关电位。社交选择测试显示，与对照组相比，氯胺酮暴露的小鼠在社交时间上没有表现出与年龄相关的减少。作为青少年，氯胺酮暴露的小鼠在放射状水迷宫任务中的表现优于对照小鼠，但没有表现出与成年对照相同的年龄相关改善。这些数据支持这样一种假设，即青少年接触氯胺酮会导致大脑功能的长期变化，其特征是无法沿着正常的发育轨迹发展。
Frequent ketamine abuse in adulthood correlates with increased risk of psychosis, as well as cognitive deficits, including disruption of higher-order executive function and memory formation. Although the primary abusers of ketamine are adolescents and young adults, few studies have evaluated its effects on juvenile cognition. Therefore, the current study analyzes the effect of adolescent ketamine exposure on cognitive development. Juvenile mice (4 weeks of age) were exposed to chronic ketamine (20 mg kg−1, i.p. daily) for 14 days. Mice were tested immediately after exposure in the juvenile period (7 weeks of age) and again as adults (12 weeks of age). Measures included electroencephalography (EEG) in response to auditory stimulation, the social choice test, and a 6-arm radial water maze task. Outcome measures include low-frequency EEG responses, event-related potential (ERP) amplitudes, indices of social behavior and indices of spatial working memory. Juvenile exposure to ketamine was associated with electrophysiological abnormalities in adulthood, particularly in induced theta power and the P80 ERP. The social choice test revealed that ketamine-exposed mice failed to exhibit the same age-related decrease in social interaction time as controls. Ketamine-exposed mice outperformed control mice as juveniles on the radial water maze task, but did not show the same age-related improvement as adult controls. These data support the hypothesis that juvenile exposure to ketamine produces long-lasting changes in brain function that are characterized by a failure to progress along normal developmental trajectories.
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DOI：
10.1002/ar.21318
发表时间：
2011-10
影响因子：
2
作者：
Fairless, Andrew H.;Shah, Rhia Y.;Guthrie, Ashley J.;Li, Hongzhe;Brodkin, Edward S.
通讯作者：
Brodkin, Edward S.
影响因子：
4.7
作者：
Bodatsch, Mitja;Klosterkotter, Joachim;Daumann, Jorg
通讯作者：
Daumann, Jorg
影响因子：
3.3
作者：
Ehrlichman, R. S.;Gandal, M. J.;Siegel, S. J.
通讯作者：
Siegel, S. J.
影响因子：
13.3
作者：
Archer, J. R. H.;Dargan, P. I.;Wood, D. M.
通讯作者：
Wood, D. M.
影响因子：
10.7
作者：
Craven, R.
通讯作者：
Craven, R.