Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise.
Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise.
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DOI:
10.1016/j.stem.2018.02.009
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发表时间:
2018-03-01
期刊:
影响因子:
23.9
通讯作者:
Chen CS
中科院分区:
文献类型:
--
作者:
Song HG;Rumma RT;Ozaki CK;Edelman ER;Chen CS
Although the clinical demand for bioengineered blood vessels continues to rise, current options for vascular conduits remain limited. The synergistic combination of emerging advances in tissue fabrication and stem cell engineering promises new strategies for engineering autologous blood vessels that recapitulate not only the mechanical properties of native vessels but also their biological function. Here we explore recent bioengineering advances in creating functional blood macro and microvessels, particularly featuring stem cells as a seed source. We also highlight progress integrating engineered vascular tissues with the host following implantation, as well as the exciting pre-clinical and clinical applications of this technology.
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