Neurologic symptoms in licensed private pesticide applicators in the agricultural health study.
Neurologic symptoms in licensed private pesticide applicators in the agricultural health study.
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DOI：
10.1289/ehp.7645
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发表时间：
2005-07
影响因子：
10.4
通讯作者：
Sandler DP
中科院分区：
文献类型：
--
作者：
Kamel F;Engel LS;Gladen BC;Hoppin JA;Alavanja MC;Sandler DP
暴露于高水平的许多农药具有急性和长期的神经后果，但对慢性暴露于中等水平的农药的神经毒性知之甚少。我们分析了1993-1997年参加农业健康研究的18，782名有执照的私人农药施用者的横截面数据。白色男性。施用者提供了关于农药终生使用情况和23种通常与农药中毒有关的神经系统症状的信息。更多症状的指标（≥10 vs. < 10）与杀虫剂用途：的累积使用天数相关：比值比（95%置信区间）为1.64（1.36-1.97），51-500天为1.89（1.58-2.25），> 500天为2.50（2.00-3.13）。观察到熏蒸剂[> 50天，1.50（1.24-1.81）]的适度相关性，除草剂[> 500天，1.32（0.99-1.75）]和杀菌剂[> 50天，1.23（1.00-1.50）]的相关性较弱。登记前一年内使用农药与症状计数无关。只有协会与杀虫剂和熏蒸剂坚持所有四个农药组同时进行了检查。在杀虫剂的化学类别中，有机磷和有机氯的关联性最强。在排除了有农药中毒史或经历过涉及高个人农药暴露事件的个人后，与累积暴露的相关性仍然存在。这些结果表明，自我报告的神经系统症状与累积暴露于中等水平的熏蒸剂和有机磷和有机氯杀虫剂，无论最近的暴露或中毒史。
Exposure to high levels of many pesticides has both acute and long-term neurologic consequences, but little is known about the neurotoxicity of chronic exposure to moderate levels of pesticides. We analyzed cross-sectional data from 18,782 white male licensed private pesticide applicators enrolled in the Agricultural Health Study in 1993–1997. Applicators provided information on lifetime pesticide use and 23 neurologic symptoms typically associated with pesticide intoxication. An indicator of more symptoms (≥10 vs. < 10) during the year before enrollment was associated with cumulative lifetime days of insecticide use: odds ratios (95% confidence intervals) were 1.64 (1.36–1.97) for 1–50 days, 1.89 (1.58–2.25) for 51–500 days, and 2.50 (2.00–3.13) for > 500 days, compared with never users. A modest association for fumigants [> 50 days, 1.50 (1.24–1.81)] and weaker relationships for herbicides [> 500 days, 1.32 (0.99–1.75)] and fungicides [> 50 days, 1.23 (1.00–1.50)] were observed. Pesticide use within the year before enrollment was not associated with symptom count. Only associations with insecticides and fumigants persisted when all four pesticide groups were examined simultaneously. Among chemical classes of insecticides, associations were strongest for organophosphates and organochlorines. Associations with cumulative exposure persisted after excluding individuals who had a history of pesticide poisoning or had experienced an event involving high personal pesticide exposure. These results suggest that self-reported neurologic symptoms are associated with cumulative exposure to moderate levels of fumigants and organophosphate and organochlorine insecticides, regardless of recent exposure or history of poisoning.
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影响因子：
8.3
作者：
Alavanja, MCR;Sandler, DP;Blair, A
通讯作者：
Blair, A
DOI：
10.1080/00039896.1988.9934372
发表时间：
1988-01-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
SAVAGE, EP;KEEFE, TJ;BURCAR, PJ
通讯作者：
BURCAR, PJ
影响因子：
12.7
作者：
Calvert, GM;Mueller, CA;Steenland, K
通讯作者：
Steenland, K
影响因子：
6.3
作者：
Gomes, J;Lloyd, O;Basha, M
通讯作者：
Basha, M
影响因子：
10.4
作者：
Kamel F;Hoppin JA
通讯作者：
Hoppin JA