Lung cancer incidence trends by gender, race and histology in the United States, 1973-2010.
Lung cancer incidence trends by gender, race and histology in the United States, 1973-2010.
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DOI：
10.1371/journal.pone.0121323
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Cote ML
中科院分区：
文献类型：
--
作者：
Meza R;Meernik C;Jeon J;Cote ML
肺癌（LC）在美国的发病率持续下降，但在组织学、性别和种族方面存在显著差异。自80年代中期以来，鳞状细胞癌、大细胞癌和小细胞癌的发病率一直在下降，而男性的腺癌发病率保持稳定，女性的腺癌发病率继续上升，种族差异很大。我们通过组织学分析了LC在美国的发病率趋势，并强调了性别和种族差异。1973-2010年的LC发病率来自SEER癌症登记处。使用关节点回归评估按性别和种族划分的五种主要组织学类型的年龄调整发病率趋势。分析2005-2010年LC的组织学及分期分布趋势。美国LC的发病率因组织学而异。鳞状细胞癌、大细胞癌和小细胞癌的发病率在所有性别/种族组合中持续下降，而腺癌的发病率在男性中保持相对稳定，在女性中呈上升趋势。自2005年以来，鳞状细胞癌和腺癌的发病率明显增加，这可以解释为其他非小细胞癌的病例数量同时减少。黑人男性仍然不成比例地受到鳞状上皮细胞癌的影响，黑人仍然比白人更容易被诊断为晚期癌症。LC的组织学发生率随时间持续变化。随着筛查的普及，预计会有更多的变化。重要的是继续监测LC率，以评估筛查对当前趋势的影响，评估烟草控制的持续效益，并集中精力减少种族差异。
Lung cancer (LC) incidence in the United States (US) continues to decrease but with significant differences by histology, gender and race. Whereas squamous, large and small cell carcinoma rates have been decreasing since the mid-80s, adenocarcinoma rates remain stable in males and continue to increase in females, with large racial disparities. We analyzed LC incidence trends by histology in the US with an emphasis on gender and racial differences. LC incidence rates from 1973–2010 were obtained from the SEER cancer registry. Age-adjusted incidence trends of five major histological types by gender and race were evaluated using joinpoint regression. Trends of LC histology and stage distributions from 2005–2010 were analyzed. US LC incidence varies by histology. Squamous, large and small cell carcinoma rates continue to decrease for all gender/race combinations, whereas adenocarcinoma rates remain relatively constant in males and increasing in females. An apparent recent increase in the incidence of squamous cell carcinoma and adenocarcinoma since 2005 can be explained by a concomitant decrease in the number of cases classified as other non-small cell carcinoma. Black males continue to be disproportionally affected by squamous LCs, and blacks continue to be diagnosed with more advanced cancers than whites. LC incidence by histology continues to change over time. Additional variations are expected as screening becomes disseminated. It is important to continue to monitor LC rates to evaluate the impact of screening on current trends, assess the continuing benefits of tobacco control, and focus efforts on reducing racial disparities.
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影响因子：
2.3
作者：
Burns, David M.;Anderson, Christy M.;Gray, Nigel
通讯作者：
Gray, Nigel
影响因子：
9.6
作者：
Khuder, SA;Mutgi, AB
通讯作者：
Mutgi, AB
DOI：
10.1158/1940-6207.capr-08-0082
发表时间：
2008-09
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Etzel CJ;Kachroo S;Liu M;D'Amelio A;Dong Q;Cote ML;Wenzlaff AS;Hong WK;Greisinger AJ;Schwartz AG;Spitz MR
通讯作者：
Spitz MR
影响因子：
5.5
作者：
Holford, Theodore R.;Levy, David T.;Mckay, Lisa A.;Clarke, Lauren;Racine, Ben;Meza, Rafael;Land, Stephanie;Jeon, Jihyoun;Feuer, Eric J.
通讯作者：
Feuer, Eric J.
影响因子：
6.2
作者：
Ma, Jiemin;Ward, Elizabeth M.;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin