Complex Interactions Between Circulating Fatty Acid Levels, Desaturase Activities, and the Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study.
Complex Interactions Between Circulating Fatty Acid Levels, Desaturase Activities, and the Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study.
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循环脂肪酸水平、去饱和酶活性和妊娠糖尿病风险之间的复杂相互作用：一项前瞻性队列研究
DOI：
10.3389/fnut.2022.919357
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发表时间：
2022
影响因子：
5
通讯作者：
Baker, Philip N.
中科院分区：
文献类型：
--
作者：
Liu, Yue;Xia, Yin-Yin;Zhang, Ting;Yang, Yang;Cannon, Richard D.;Mansell, Toby;Novakovic, Boris;Saffery, Richard;Han, Ting-Li;Zhang, Hua;Baker, Philip N.
关键词：
此前，孕妇的异常脂肪酸降低与妊娠期糖尿病(GDM)有关。然而，很少有研究对这种关系在整个怀孕期间进行纵向研究。在这项研究中，我们调查了妊娠三个月期间妊娠期糖尿病与去饱和酶活性的关系。共有661名妇女(妊娠期糖尿病=189名，非妊娠期糖尿病=472名)从母亲和婴儿的复杂血脂(攀登)队列研究中挑选出来。分别于妊娠11-14周、22-28周、32-34周采集母体血清和临床资料。用气相色谱-质谱仪(GC-MS)对各时间点的20种血清脂肪酸进行定量。多不饱和脂肪酸(PUFA)产物与前体的比值被用来评估脱饱和酶和延伸酶的活性，包括Delta-5去饱和酶、Delta-6去饱和酶、硬脂酰辅酶A去饱和酶和延伸酶。在调整了包括母亲年龄、体重指数、初产、吸烟和饮酒在内的主要潜在混杂因素后，我们观察到与非妊娠期糖尿病组相比，妊娠早期孕妇的γ-亚麻酸(GLA)和二十碳三烯酸(DGLA)水平显著增加，而GLA和DGLA在妊娠晚期降低。妊娠期糖尿病组花生四烯酸(AA)水平在整个孕期呈上升趋势。与对照组相比，妊娠早期GDM患者的Delta-6和Delta-5脱饱和酶活性升高(OR=1.40，95%CI 1.03~1.91；OR=0.56，95%CI 0.32~0.96)，但在妊娠晚期减弱(OR=0.78，95%CI 0.58~1.07；OR=2.64，95%CI 1.46~4.78)。妊娠晚期妊娠期糖尿病患者的Delta-9-18脱饱和酶活性升高(OR=3.70，95%CI为1.49~9.19)。我们的研究强调了脂肪酸去饱和酶活性的潜在重要性，特别是估计的Delta-5去饱和酶和Delta-9-18去饱和酶在GDM的病理生理学中的重要性。这些发现可能对妊娠期糖尿病的早期诊断和治疗有一定的应用价值。
Maternal abnormal fatty acid desaturation has previously been linked to gestational diabetes mellitus (GDM). However, few studies have investigated this relationship longitudinally throughout pregnancy. In this study, we investigated the relationship between GDM and desaturase activities across the pregnancy trimesters. A total of 661 women (GDM = 189, non-GDM = 472) were selected from the Complex Lipids in Mothers and Babies (CLIMB) cohort study. Clinical information and maternal serum were collected at 11–14, 22–28, and 32–34 weeks of gestation. Totally, 20 serum fatty acids were quantified using gas chromatography–mass spectrometry (GC-MS) analysis at each timepoint. Polyunsaturated fatty acid (PUFA) product-to-precursor ratios were used to estimate desaturase and elongase activities including delta-5 desaturase, delta-6 desaturase, stearoyl-CoA desaturase, and elongase. After adjusting for major potential confounders including maternal age, BMI, primiparity, smoking, and alcohol consumption, we observed a significant increase in the levels of γ-linolenic acid (GLA) and eicosatrienoic acid (DGLA) in the first trimester of women with GDM, whereas GLA and DGLA were reduced in the third trimester, when compared to the non-GDM group. Arachidonic acid (AA) showed an upward trend in the GDM group throughout pregnancy. Estimated delta-6 desaturase and delta-5 desaturase activity were elevated in the first trimester (OR = 1.40, 95% CI 1.03–1.91; OR = 0.56, 95% CI 0.32–0.96) but attenuated in the third trimester (OR = 0.78, 95% CI 0.58–1.07; OR = 2.64, 95% CI 1.46–4.78) in GDM pregnancies, respective to controls. Estimated delta-9–18 desaturase activity (OR = 3.70, 95% CI 1.49–9.19) was increased in women with GDM in later pregnancy. Our study highlights the potential importance of fatty acid desaturase activities, particularly estimated delta-5 desaturase and delta-9–18 desaturase in the pathophysiology of GDM. These findings may have applications for the early diagnosis and management of GDM.
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血清脂肪酸，去饱和酶活性和腹部肥胖症 - 一项基于人群的研究，对60岁的男性和女性。
影响因子：
3.7
作者：
Alsharari ZD;Risérus U;Leander K;Sjögren P;Carlsson AC;Vikström M;Laguzzi F;Gigante B;Cederholm T;De Faire U;Hellénius ML;Marklund M
通讯作者：
Marklund M
影响因子：
5.9
作者：
Andersson-Hall U;Carlsson NG;Sandberg AS;Holmäng A
通讯作者：
Holmäng A
DOI：
10.1111/dme.12381
发表时间：
2014-03
期刊：
Diabetic medicine : a journal of the British Diabetic Association
影响因子：
--
作者：
Catalano PM
通讯作者：
Catalano PM
DOI：
10.1016/j.bbalip.2008.12.011
发表时间：
2009-02
影响因子：
4.8
作者：
Flowers, Matthew I.;Ntambi, James M.
通讯作者：
Ntambi, James M.
影响因子：
44.5
作者：
He, Yuna;Li, Yanping;Hu, Frank B.
通讯作者：
Hu, Frank B.