Circulating Linoleic Acid is Associated with Improved Glucose Tolerance in Women after Gestational Diabetes.
Circulating Linoleic Acid is Associated with Improved Glucose Tolerance in Women after Gestational Diabetes.
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DOI：
10.3390/nu10111629
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发表时间：
2018-11-02
期刊：
影响因子：
5.9
通讯作者：
Holmäng A
中科院分区：
文献类型：
--
作者：
Andersson-Hall U;Carlsson NG;Sandberg AS;Holmäng A
既往诊断出妊娠期糖尿病（GDM）的女性患2型糖尿病（T2 D）的风险增加。我们的目的是建立从GDM到T2 D的转变中葡萄糖耐量（GT）和血清脂肪酸（FA）谱之间的联系。GDM后6年，221名女性根据口服GT测试结果分为正常GT（NGT）、受损GT（IGT）或T2 D。分析空腹血清脂肪酸，进行人体测量，并确定饮食摄入量。与IGT和T2 D相比，NGT女性的亚油酸（LA）显著更高（p < 0.001），并且是低血糖和低胰岛素水平的强预测因子，与BMI无关。自我报告的植物油消耗量与LA血清水平和葡萄糖水平相关。δ-6-、δ-9-和硬脂酰-CoA-去饱和酶活性与GT降低相关，δ-5-去饱和酶活性与GT增加相关。在糖尿病高危女性亚组中，在发展为T2 D的女性中观察到低LA和高棕榈酸水平，在其他FA或代谢测量中没有差异。结果表明，LA和棕榈酸的比例在GDM向T2 D的转变中特别重要。由去饱和酶调节的单个FA之间的相互转化似乎与葡萄糖代谢有关。
Women with previously diagnosed gestational diabetes mellitus (GDM) are at increased risk of type-2-diabetes mellitus (T2D). We aimed to establish links between glucose tolerance (GT) and serum fatty acid (FA) profile in the transition from GDM to T2D. Six years after GDM, 221 women were grouped as having normal GT (NGT), impaired GT (IGT), or T2D based on oral GT test results. Fasting serum FAs were profiled, anthropometric measures taken, and dietary intake determined. Linoleic acid (LA) was significantly higher in NGT women (p < 0.001) compared with IGT and T2D, and emerged as a strong predictor of low glucose and insulin levels, independently of BMI. Self-reported vegetable oil consumption correlated with LA serum levels and glucose levels. Delta-6-, delta-9-, and stearoyl-CoA-desaturase activities were associated with decreased GT, and delta-5-desaturase activities with increased GT. In a subgroup of women at high risk of diabetes, low LA and high palmitic acid levels were seen in those that developed T2D, with no differences in other FAs or metabolic measurements. Results suggest that proportions of LA and palmitic acid are of particular interest in the transition from GDM to T2D. Interconversions between individual FAs regulated by desaturases appear to be relevant to glucose metabolism.
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影响因子：
5.9
作者：
Brayner B;Kaur G;Keske MA;Livingstone KM
通讯作者：
Livingstone KM
影响因子：
3.7
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作者：
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通讯作者：
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