Generation and Thermal Simulation of a Digital Model of the Female Breast in Prone Position
Generation and Thermal Simulation of a Digital Model of the Female Breast in Prone Position
复制标题
俯卧位女性乳房数字模型的生成和热模拟
DOI：
10.1115/1.4041421
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Phatak, Pradyumna
中科院分区：
文献类型：
--
作者：
Gonzalez-Hernandez, Jose-Luis;Kandlikar, Dr. Satish;Dabydeen, Donnette;Medeiros, Lori;Phatak, Pradyumna
红外线（IR）乳腺热成像与乳腺癌（BC）的早期检测有关。然而，以前的研究结果并不确定。成像期间受试者的直立位置会导致判读错误，因为它会阻挡乳房下皱襞区域的光学通路，并由于乳房和胸壁之间的接触而改变温度。这些错误可以通过在俯卧位对乳房进行成像来避免。虽然数值模拟提供了洞察女性乳房肿瘤的热特性，在过去的大多数模拟使用立方体和半球形乳房模型。我们假设具有实际乳房形状的乳房模型将提供在肿瘤检测中有用的真实热特性。建立了一个俯卧位乳腺数字模型，用于生成乳腺肿瘤的表面温度分布。数字乳腺模型是从序列磁共振成像（MRI）图像生成的，并使用有限体积法采用Pennes生物热方程进行模拟。我们研究了不同的肿瘤代谢活动对表面温度分布的影响。我们将各种肿瘤代谢活动的表面温度曲线与无肿瘤病例进行了比较。肿瘤位置附近的表面温度上升在0.665至1.023 °C之间，使用现代红外相机可检测到。这是第一次，数值模拟进行了一个模型与实际的乳房形状在俯卧位，以研究表面温度变化引起的BC。
Infrared (IR) breast thermography has been associated with the early detection of breast cancer (BC). However, findings in previous studies have been inconclusive. The upright position of subjects during imaging introduces errors in interpretation, because it blocks the optical access in the inframammary fold region and alters the temperature due to contact between breast and chest wall. These errors can be avoided by imaging breasts in prone position. Although the numerical simulations provide insight into thermal characteristics of the female breast with a tumor, most simulations in the past have used cubical and hemispherical breast models. We hypothesize that a breast model with the actual breast shape will provide true thermal characteristics that are useful in tumor detection. A digital breast model in prone position is developed to generate the surface temperature profiles for breasts with tumors. The digital breast model is generated from sequential magnetic resonance imaging (MRI) images and simulations are performed using finite volume method employing Pennes bioheat equation. We investigated the effect of varying the tumor metabolic activity on the surface temperature profile. We compared the surface temperature profile for various tumor metabolic activities with a case without tumor. The resulting surface temperature rise near the location of the tumor was between 0.665 and 1.023 °C, detectable using modern IR cameras. This is the first time that numerical simulations are conducted in a model with the actual breast shape in prone position to study the surface temperature changes induced by BC.
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DOI：
10.1111/j.1749-6632.1980.tb50764.x
发表时间：
1980-01-01
影响因子：
5.2
作者：
Gautherie, M
通讯作者：
Gautherie, M
在已知皮肤表面温度的情况下估计乳腺组织中的肿瘤特征
影响因子：
2.7
作者：
K. Das;S. Mishra
通讯作者：
S. Mishra
皮肤发射率的波长依赖性。
影响因子：
3.5
作者：
D. Watmough;R. Oliver
通讯作者：
R. Oliver
DOI：
10.1243/0954411011535975
发表时间：
2001-01-01
影响因子：
1.8
作者：
Ng, EYK;Sudharsan, NM
通讯作者：
Sudharsan, NM
DOI：
10.1243/0954411001535534
发表时间：
2000-01-01
影响因子：
1.8
作者：
Sudharsan, NM;Ng, EYK
通讯作者：
Ng, EYK