Zinc is a novel intracellular second messenger.
Zinc is a novel intracellular second messenger.
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锌是一种新颖的细胞内第二信使。
DOI：
10.1083/jcb.200702081
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发表时间：
2007-05-21
影响因子：
7.8
通讯作者：
Hirano, Toshio
中科院分区：
文献类型：
--
作者：
Yamasaki, Satoru;Sakata-Sogawa, Kumiko;Hasegawa, Aiko;Suzuki, Tomoyuki;Kabu, Koki;Sato, Emi;Kurosaki, Tomohiro;Yamashita, Susumu;Tokunaga, Makio;Nishida, Keigo;Hirano, Toshio
锌是酶活性和维持许多转录因子构象所必需的微量元素；因此，锌的体内平衡受到严格调节。虽然锌可以影响多种信号分子，并可能作为神经递质，但锌是否作为细胞内第二信使，能够将细胞外刺激转化为细胞内信号事件，目前尚不清楚。在这项研究中，我们报道了高亲和力的免疫球蛋白E受体（Fc受体I [Fc]）的交联诱导游离锌从核周区域释放，包括肥大细胞的内质网，我们称之为锌波的现象。锌波依赖于钙内流和丝裂原激活的蛋白激酶/细胞外信号调节的激酶活化。结果表明，锌波参与细胞内信号事件，至少部分是通过调节Fc i介导的信号传导的持续时间和强度。总的来说，我们的发现表明锌是一种新的细胞内第二信使。
Zinc is an essential trace element required for enzymatic activity and for maintaining the conformation of many transcription factors; thus, zinc homeostasis is tightly regulated. Although zinc affects several signaling molecules and may act as a neurotransmitter, it remains unknown whether zinc acts as an intracellular second messenger capable of transducing extracellular stimuli into intracellular signaling events. In this study, we report that the cross-linking of the high affinity immunoglobin E receptor (Fcɛ receptor I [FcɛRI]) induced a release of free zinc from the perinuclear area, including the endoplasmic reticulum in mast cells, a phenomenon we call the zinc wave. The zinc wave was dependent on calcium influx and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase activation. The results suggest that the zinc wave is involved in intracellular signaling events, at least in part by modulating the duration and strength of FcɛRI-mediated signaling. Collectively, our findings indicate that zinc is a novel intracellular second messenger.
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DOI：
10.1073/pnas.76.1.457
发表时间：
1979-01-01
影响因子：
11.1
作者：
FERNANDES, G;NAIR, M;GOOD, RA
通讯作者：
GOOD, RA
影响因子：
4.2
作者：
Ibs, KH;Rink, L
通讯作者：
Rink, L
DOI：
10.1073/pnas.96.5.1936
发表时间：
1999-03-02
影响因子：
11.1
作者：
Maret, W;Jacob, C;Fischer, EH
通讯作者：
Fischer, EH
影响因子：
4.7
作者：
Aizenman, E;Stout, AK;Reynolds, IJ
通讯作者：
Reynolds, IJ
影响因子：
4.4
作者：
Hashimoto, A;Takeda, K;Kurosaki, T
通讯作者：
Kurosaki, T