Iodinated NanoClusters as an inhaled computed tomography contrast agent for lung visualization.
Iodinated NanoClusters as an inhaled computed tomography contrast agent for lung visualization.
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DOI：
10.1021/mp1000718
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发表时间：
2010-08-02
影响因子：
4.9
通讯作者：
Berkland C
中科院分区：
文献类型：
--
作者：
Aillon KL;El-Gendy N;Dennis C;Norenberg JP;McDonald J;Berkland C
造影剂配方的改进可能是提高胸部计算机断层扫描（CT）成像在疾病评估中的准确性和有效性的有效方法。为了达到肺部的造影剂增强效果，必须给予相对高浓度的局部造影剂。吸入为局部肺输送提供了一种非侵入性的胸膜内注射替代方法，但有效的雾化可能会阻碍成功的成像策略。本文将纳米聚类技术应用于二三甲酸衍生物N1177，制备了气动直径≤5µm的低密度纳米颗粒团聚体。不含赋形剂的N1177 NanoCluster粉末通过灌胃或吸入给药给鼠，并在给药后2小时用CT扫描。吸入后CT图像显示肺部造影剂升高~ 120hu，对胸部CT成像造影剂已足够。肺组织组织学显示N1177纳米簇对肺无损伤。纳米簇粒子工程技术提供了一种安全有效地将高浓度造影剂扩散到肺周围的新方法。
Improvements to contrast media formulations may be an effective way to increase the accuracy and effectiveness of thoracic computed tomography (CT) imaging in disease evaluation. To achieve contrast enhancement in the lungs, a relatively large localized concentration of contrast media must be delivered. Inhalation offers a non-invasive alternative to intrapleural injections for local lung delivery, but effective aerosolization may deter successful imaging strategies. Here, NanoCluster technology was applied to N1177, a diatrizoic acid derivative, to formulate low density nanoparticle agglomerates with aerodynamic diameters ≤ 5 µm. Excipient-free N1177 NanoCluster powders were delivered to rats by insufflation or inhalation and scanned using CT up to 2 h post dose. CT images after inhalation showed a ~120 HU contrast increase in the lungs, which was more than sufficient contrast for thoracic CT imaging. Lung tissue histology demonstrated that N1177 NanoClusters did not damage the lungs. NanoCluster particle engineering technology offers a novel approach to safely and efficiently disseminate high concentrations of contrast agents to the lung periphery.
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