A maternal-offspring coadaptation theory for the evolution of genomic imprinting.
A maternal-offspring coadaptation theory for the evolution of genomic imprinting.
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DOI：
10.1371/journal.pbio.0040380
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发表时间：
2006-11
期刊：
影响因子：
9.8
通讯作者：
Hager R
中科院分区：
文献类型：
--
作者：
Wolf JB;Hager R
印记基因仅从母系或父系遗传的拷贝表达，并且它们在调节复杂的生物过程中起关键作用，包括后代发育和母子相互作用。有几个相互竞争的理论试图解释这种基因表达的单等位基因模式的进化起源，但一个流行的观点已经出现，认为基因组印记是母亲和父亲的基因拷贝之间的冲突的结果超过母亲的投资。然而，许多印记模式和明显过剩的母系表达基因仍然无法解释，可能与当前的理论不一致。在这里，我们证明了母体基因拷贝的单独表达受到自然选择的青睐，因为它增加了后代和母体基因组的适应性整合，从而导致更高的后代适应性。这种新的共适应理论的基因组印迹的进化是一致的，最近的研究结果表观遗传效应，它提供了一个可检验的假说，以前无法解释的主要印迹模式的起源在不同的类群。结合现有的假设，我们的研究结果表明，印记可能是由于在不同的位点不同的选择压力。本文从理论上证明了母子共适应（对父母和后代基因组合的选择）可以选择后代性状的基因组印记。
Imprinted genes are expressed either from the maternally or paternally inherited copy only, and they play a key role in regulating complex biological processes, including offspring development and mother–offspring interactions. There are several competing theories attempting to explain the evolutionary origin of this monoallelic pattern of gene expression, but a prevailing view has emerged that holds that genomic imprinting is a consequence of conflict between maternal and paternal gene copies over maternal investment. However, many imprinting patterns and the apparent overabundance of maternally expressed genes remain unexplained and may be incompatible with current theory. Here we demonstrate that sole expression of maternal gene copies is favored by natural selection because it increases the adaptive integration of offspring and maternal genomes, leading to higher offspring fitness. This novel coadaptation theory for the evolution of genomic imprinting is consistent with results of recent studies on epigenetic effects, and it provides a testable hypothesis for the origin of previously unexplained major imprinting patterns across different taxa. In conjunction with existing hypotheses, our results suggest that imprinting may have evolved due to different selective pressures at different loci. This theoretical paper demonstrates that maternal-offspring coadaptation (the selection for gene combinations of parents and offspring) could select for genomic imprinting of the offspring trait.
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影响因子：
6.5
作者：
Jarvis, JP;Kenney-Hunt, J;Cheverud, JM
通讯作者：
Cheverud, JM
DOI：
10.1098/rspb.2000.1259
发表时间：
2000-10-22
影响因子：
4.7
作者：
Kölliker, M;Brinkhof, MWG;Richner, H
通讯作者：
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影响因子：
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Li, LL;Keverne, EB;Surani, MA
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影响因子：
2.1
作者：
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通讯作者：
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DOI：
10.1073/pnas.081540898
发表时间：
2001-04-10
影响因子：
11.1
作者：
Georgiades, P;Watkins, M;Ferguson-Smith, AC
通讯作者：
Ferguson-Smith, AC