Eco-geographical diversification of bitter taste receptor genes (TAS2Rs) among subspecies of chimpanzees (Pan troglodytes).
Eco-geographical diversification of bitter taste receptor genes (TAS2Rs) among subspecies of chimpanzees (Pan troglodytes).
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DOI：
10.1371/journal.pone.0043277
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Imai H
中科院分区：
文献类型：
--
作者：
Hayakawa T;Sugawara T;Go Y;Udono T;Hirai H;Imai H
在热带非洲，黑猩猩的饮食习惯从东到西具有地区特异性的差异。这种差异可能是由于不同的遗传背景和文化差异造成的。我们分析了59只黑猩猩的所有苦味受体基因(CTAS2Rs)的序列，其中包括4个可能的亚种。我们鉴定了cTAS2R的遗传变异，包括单核苷酸变异(SNV)、插入和缺失(INDELs)、基因转换变异和拷贝数变异(CNV)。氨基酸序列中约三分之二的cTAS2R单倍型是每个亚种所特有的。我们分析了这种多样性背后的自然选择的进化背景。我们之前的研究得出结论，西部黑猩猩(P.T.verus)cTAS2Rs的多样化可能是平衡选择的结果。相反，本研究发现，在东部黑猩猩(P.T.schweinFurthii)中，净化选择是所谓的cTAS2R人类簇多样化的进化形式，而其他cTAS2R作为一个整体没有受到明显的选择。这种具有不同进化背景的cTAS2R在黑猩猩亚种之间的显着多样性可能反映了它们特定亚种的饮食结构。
Chimpanzees (Pan troglodytes) have region-specific difference in dietary repertoires from East to West across tropical Africa. Such differences may result from different genetic backgrounds in addition to cultural variations. We analyzed the sequences of all bitter taste receptor genes (cTAS2Rs) in a total of 59 chimpanzees, including 4 putative subspecies. We identified genetic variations including single-nucleotide variations (SNVs), insertions and deletions (indels), gene-conversion variations, and copy-number variations (CNVs) in cTAS2Rs. Approximately two-thirds of all cTAS2R haplotypes in the amino acid sequence were unique to each subspecies. We analyzed the evolutionary backgrounds of natural selection behind such diversification. Our previous study concluded that diversification of cTAS2Rs in western chimpanzees (P. t. verus) may have resulted from balancing selection. In contrast, the present study found that purifying selection dominates as the evolutionary form of diversification of the so-called human cluster of cTAS2Rs in eastern chimpanzees (P. t. schweinfurthii) and that the other cTAS2Rs were under no obvious selection as a whole. Such marked diversification of cTAS2Rs with different evolutionary backgrounds among subspecies of chimpanzees probably reflects their subspecies-specific dietary repertoires.
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影响因子：
10.7
作者：
Campbell, Michael C.;Ranciaro, Alessia;Tishkoff, Sarah A.
通讯作者：
Tishkoff, Sarah A.
影响因子：
9.2
作者：
Fischer, Anne;Pollack, Joshua;Paeaebo, Svante
通讯作者：
Paeaebo, Svante
影响因子：
64.8
作者：
Matsunami, H;Montmayeur, JP;Buck, LB
通讯作者：
Buck, LB
影响因子：
64.5
作者：
Adler, E;Hoon, MA;Zuker, CS
通讯作者：
Zuker, CS
DOI：
10.1098/rspb.2010.1112
发表时间：
2011-02-07
影响因子：
4.7
作者：
Langergraber, Kevin E.;Boesch, Christophe;Vigilant, Linda
通讯作者：
Vigilant, Linda