Measurement of glycine in gray and white matter in the human brain in vivo by 1H MRS at 7.0 T.
Measurement of glycine in gray and white matter in the human brain in vivo by 1H MRS at 7.0 T.
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DOI：
10.1002/mrm.24368
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发表时间：
2012-08
影响因子：
3.3
通讯作者：
Choi, Changho
中科院分区：
文献类型：
--
作者：
Banerjee, Abhishek;Ganji, Sandeep;Hulsey, Keith;Dimitrov, Ivan;Maher, Elizabeth;Ghose, Subroto;Tamminga, Carol;Choi, Changho
本文采用7 T的单像素定位~ 1H-MRS技术，测定了人脑灰质和白色质中甘氨酸（Gly）的含量。使用TE = 150 ms的点分辨光谱（PRESS）序列测量11名健康志愿者和1名胶质母细胞瘤受试者额叶和枕叶各区域的Gly水平。使用密度矩阵模拟生成的基函数（包括体积局部射频和梯度脉冲的影响），使用LCModel分析PRESS光谱。从T1加权图像分割获得体素内的灰色和白色物质的分数。体素内的代谢物浓度，估计相对于GM+WM水浓度，拟合到GM含量分数的线性函数。纯GM和WM中的Gly浓度估计为1.1和0.1 mM，95%置信区间分别为1.0 - 1.2和0.0 - 0.2。
The concentration of glycine (Gly) was measured in gray and white matter (GM and WM) in the human brain using single-voxel localized 1H-MRS at 7 T. A point-resolved spectroscopy (PRESS) sequence with TE = 150 ms was used for measuring Gly levels in various regions of the frontal and occipital lobes in eleven healthy volunteers and one subject with a glioblastoma. The PRESS spectra were analyzed with LCModel using basis functions generated from density matrix simulations that included the effects of volume localized radio-frequency and gradient pulses. The fraction of gray and white matter within the voxels was obtained from T1-weighted image segmentation. The metabolite concentrations within the voxels, estimated with respect to the GM+WM water concentrations, were fitted to a linear function of fractional GM content. The Gly concentrations in pure GM and WM were estimated to be 1.1 and 0.1 mM, with 95% confidence intervals 1.0 - 1.2 and 0.0 - 0.2, respectively.
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影响因子：
3.3
作者：
Choi, Changho;Ganji, Sandeep K.;DeBerardinis, Ralph J.;Dimitrov, Ivan E.;Pascual, Juan M.;Bachoo, Robert;Mickey, Bruce E.;Malloy, Craig R.;Maher, Elizabeth A.
通讯作者：
Maher, Elizabeth A.
DOI：
10.1007/s10334-008-0145-z
发表时间：
2009-02-01
影响因子：
2.3
作者：
Hattingen, Elke;Lanfermann, Heinrich;Pilatus, Ulrich
通讯作者：
Pilatus, Ulrich
影响因子：
2.9
作者：
Boer, Vincent O.;Siero, Jeroen C. W.;Klomp, Dennis W. J.
通讯作者：
Klomp, Dennis W. J.
影响因子：
3.3
作者：
KLOSE, U
通讯作者：
KLOSE, U
影响因子：
2.9
作者：
Emir, Uzay E.;Deelchand, Dinesh;Henry, Pierre-Gilles;Terpstra, Melissa
通讯作者：
Terpstra, Melissa